CIENCIASMEDICASNEWS: Cell Culture Clarification Expressing Recombinant Antibodies

miércoles, 23 de enero de 2019

Cell Culture Clarification Expressing Recombinant Antibodies

	January 23, 2019
	Immunology
	The latest immunology news from News Medical

Lab-Scale Clarificationof Mammalian Cell Cultures Expressing Recombinant Antibodies

Tina Stoschek and Marcus Gerlach discuss maximizing mAb generation using lab-scale clarification of cell cultures expressing recombinant antibodies.

			Fluorescence-Activated Cell Sorting (FACS) - Immune Checkpoint Proteins Immune checkpoint proteins have attracted more and more attention over the past couple of years due to their role in cancer development. Researchers have discovered that tumor cells can ‘hijack’ the checkpoint pathways of these proteins to avoid attacks from the immune system.

			Researchers Create Nanoparticle that Targets Tumor-Infiltrating Immune Cells to Eliminate Cancer Cells The potential of immunotherapy in the battle against cancer attracted international interest after two researchers received the coveted Nobel Prize for exposing the ability of the immune system to remove tumor cells.

	Stress related pathway instrumental in controlling function of immune cells The immune system is composed of a wide range of different immune cells each with dedicated functions. Natural killer T cells form a specialized immune cell that protects against a variety of diseases such as cancer, autoimmunity, metabolic disease or certain infections such as Lyme disease.

	Researchers manipulate T cells to improve transplant success Researchers have manipulated T cells in a way that prevents the rejection of transplanted organs, without affecting the immune system’s ability to fight microbial infection.

	New Study Describes an Important Step in Activation of the Immune System Against Nanoparticles Doctors would prefer to use all kinds of nanoparticles in the body, for instance, to create comprehensive images of anatomy and disease, and to deliver cancer-fighting drugs deep inside the tumor tissue.

	Hyperactive immune system implicated in aging brain disorders In a study of fruit flies, NIH scientists suggested that the body's immune system may play a critical role in the damage caused by aging brain disorders. The results are based on experiments in which the researchers altered the activity of Cdk5, a gene that preclinical studies have suggested is important for early brain development and may be involved in neurodegenerative diseases, such as ALS, Alzheimer's and Parkinson's disease.

	New evidence shows how fever alters immune cells Fever is known to help power up our immune cells, and scientists in Shanghai have new evidence explaining how. They found in mice that fever alters surface proteins on immune cells like lymphocytes to make them better able to travel via blood vessels to reach the site of infection. Their work appears on January 15 in the journal Immunity.