Single-Chain Antibodies Directed to Norovirus GI.1 and GII.4 and Their Use | Office of Technology Transfer, NIH

Single-Chain Antibodies Directed to Norovirus GI.1 and GII.4 and Their Use | Office of Technology Transfer, NIH

Collaborative Research and Licensing Opportunity:

Llama-Derived Nanoantibodies With Therapeutic Potential Against Human Norovirus

This digitally colorized, transmission electron microscopic (TEM) image reveals some of the ultrastructural morphology displayed by a cluster of norovirus virions. Photo credit: CDC



Llama-derived single chain antibody fragments (VHH) are small, recombinant monoclonal antibodies with several advantages over conventional antibodies. NIAID scientists have isolated VHH monoclonal antibodies from llamas that showed strong neutralizing activity against norovirus in in vitro assays. These nanobodies may have application as immunoprophylaxis to protect individuals from infections or as a possible treatment for infected individuals, they can be used to develop a diagnostic for detection of norovirus infections, and they could be used in vaccine research. Read more about this exciting collaboration opportunity: https://www.ott.nih.gov/technology/e-136-2013-0 .