Vol. 67, No. 6
February 16, 2018
Health-Risk Behaviors and Chronic Conditions Among Adults with Inflammatory Bowel Disease — United States, 2015 and 2016
Weekly / February 16, 2018 / 67(6);190–195
Fang Xu, PhD1; James M. Dahlhamer, PhD2; Emily P. Zammitti, MPH2; Anne G. Wheaton, PhD1; Janet B. Croft, PhD1 (View author affiliations)View suggested citation
Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. In 2015, an estimated 3.1 million adults in the United States had ever received a diagnosis of IBD (1). Nationally representative samples of adults with IBD have been unavailable or too small to assess relationships between IBD and other chronic conditions and health-risk behaviors (2). To assess the prevalence of health-risk behaviors and chronic conditions among adults with and without IBD, CDC aggregated survey data from the 2015 and 2016 National Health Interview Survey (NHIS). An estimated 3.1 million (unadjusted lifetime prevalence = 1.3%) U.S. adults had ever received a diagnosis of IBD. Adults with IBD had a significantly lower prevalence of having never smoked cigarettes than did adults without the disease (55.9% versus 63.5%). Adults with IBD had significantly higher prevalences than did those without the disease in the following categories: having smoked and quit (26.0% versus 21.0%; having met neither aerobic nor muscle-strengthening activity guidelines (50.4% versus 45.2%); reporting <7 hours of sleep, on average, during a 24-hour period (38.2% versus 32.2%); and having serious psychological distress (7.4% versus 3.4%). In addition, nearly all of the chronic conditions evaluated were more common among adults with IBD than among adults without IBD. Understanding the health-risk behaviors and prevalence of certain chronic conditions among adults with IBD could inform clinical practice and lead to better disease management.
The NHIS is a cross-sectional household health survey of the civilian noninstitutionalized population. The survey provides nationally representative data on a broad range of topics, including health status, health behaviors, and access to and use of health care.* Data on diagnosed IBD (hereafter referred to as IBD) were collected with the Sample Adult Core questionnaire using the following question: “Have you ever been told by a doctor or other health professional that you had Crohn’s disease or ulcerative colitis?” The sample adult is randomly selected from all adults aged ≥18 years in the family and answers for himself/herself (unless physically or mentally unable to do so, in which case a knowledgeable adult serves as a proxy respondent). Interviews are conducted in respondents’ homes, although follow-ups by telephone to complete missing sections are permitted. To ensure more precise estimates of IBD status, the 2015 and 2016 Sample Adult data files were combined with the 2-year response rate of 54.7%.†
The prevalence of IBD, with 95% confidence intervals, was estimated for the civilian, noninstitutionalized U.S. adult population overall and by various sociodemographic characteristics. These characteristics, collected with the Household Composition and Family Core questionnaires, included age, sex, race/ethnicity, education level, marital status, current employment status, nativity, health insurance coverage type (reported separately for adults aged <65 and ≥65 years), urbanicity, and region of residence. Next, the prevalence of five health-risk behaviors§ (cigarette smoking status, binge drinking, body mass index [BMI] category, meeting of federal physical activity guidelines, and short sleep duration), serious psychological distress¶ (a proxy for mental health symptoms), and several chronic conditions** (cardiovascular disease, respiratory disease, cancer, diabetes, arthritis, weak or failing kidneys, any liver condition, and ulcer) were estimated separately for adults with and without IBD. All prevalence estimates met the reliability standard of relative standard errors <30%†† and were age-adjusted to the projected 2000 U.S. population§§ (unless otherwise noted). For comparison of IBD prevalence by subgroup and prevalence of health-risk behaviors and chronic conditions by IBD status, differences were considered significant if two-tailed Z-tests yielded p-values <0.05. All comparisons described in the results were statistically significant. All analyses were conducted using statistical software to account for the stratified, complex cluster sampling design of the survey. Estimates incorporated the final sample adult weights adjusted for nonresponse and calibrated to population control totals to generalize the estimates to the civilian noninstitutionalized population aged ≥18 years.
In 2015 and 2016, 3.1 million (unadjusted lifetime prevalence of 1.3%; age-adjusted lifetime prevalence of 1.2%) U.S. adults had ever received a diagnosis of IBD (Table 1). The age-specific prevalence of IBD was higher among adults aged 45–64 and ≥65 years (both 1.7%) than among those aged 18–24 (0.5%) or 25–44 (1.0%) years. The prevalence of IBD was higher among women (1.5%) than among men (1.0%); among non-Hispanic white adults (1.4%) than among non-Hispanic black adults (0.6%) or other non-Hispanic adults (0.8%); among those with less than a high school education (1.6%) than among those with at least a bachelor’s degree (1.1%); among those who were divorced, separated, or widowed (2.3%) than among persons who were married or cohabitating (1.1%); among currently unemployed (1.6%) or U.S.-born (1.3%) adults than their employed (1.1%) and non–U.S.-born (0.8%) counterparts; and among adults living in small metropolitan statistical areas (MSAs) (1.4%) than among those living in large MSAs (1.1%). The prevalence of IBD did not differ significantly among groups defined by health insurance coverage type or region of residence.
Being a former smoker was more prevalent among adults with IBD (26.0%) than among adults without IBD (21.0%), and having never smoked was less prevalent among adults with IBD (55.9%) than among those without IBD (63.5%) (Table 2). In addition, adults with IBD had higher prevalences than those without IBD of sleeping <7 hours per day (38.2% versus 32.2%) and meeting neither aerobic nor muscle-strengthening physical activity guidelines (50.4% versus 45.2%). No statistically significant difference was detected in the prevalence of binge drinking or BMI category between the two groups. The prevalence of experiencing serious psychological distress was reported twice as frequently by adults with IBD (7.4%) than by those without IBD (3.4%). Among the selected chronic conditions, with the exception of diabetes, all were significantly more prevalent among adults with IBD than among those without IBD (Table 2). The prevalence of ulcer was nearly five times higher among adults with IBD (26.0%) than among those without IBD (5.5%).
Based on a nationally representative sample, during 2015–2016, an estimated 3.1 million U.S. adults had ever received a diagnosis of IBD. IBD might require lifelong disease management, including a combination of prescription medications, surgery, and medical treatment in outpatient, inpatient, emergency department, or ambulatory care settings. The symptoms and complications of IBD are associated with substantially impaired health-related quality of life (3). The total direct and indirect costs from loss of earnings or productivity attributable to IBD in the United States were estimated in 2014 to be $14.6 billion–$31.6 billion¶¶; however, because this estimate was based on a lower prevalence of IBD than that presented in this report, and given the impact of inflation, the current costs might be substantially higher.
In this study, the prevalence of IBD was higher among women, non-Hispanic whites, and older, less educated, and unemployed adults, which is consistent with the findings of previous studies (1,4,5). For example, in a previous study using insurance claims data, the prevalence of Crohn’s disease and ulcerative colitis was higher among older adults, and although the prevalence of ulcerative colitis did not differ significantly by sex, women were more likely than men to have Crohn’s disease (4). In this study, however, the survey question did not differentiate Crohn’s disease from ulcerative colitis. This study also found IBD to be more prevalent among unemployed adults, reinforcing previous findings on the employment burden of the disease (5). However, unlike other studies (4,6), no evidence was found of a difference in IBD prevalence by region of residence, which might be a result of different data collection modes and target populations in different studies.
Adults with IBD were more frequently former smokers and less frequently never smokers than were those without IBD. Some smokers might possibly have quit smoking because of a diagnosis of IBD. The role of smoking in the development of IBD is not fully understood. Smoking among persons with Crohn’s disease, however, has been found to be associated with disease development, progression, and inferior treatment outcomes (7). Smoking cessation, therefore, is particularly recommended among patients with diagnosed Crohn’s disease (7). Many chronic conditions are more common among adults who report a short sleep duration.*** Similarly, this study found that short sleep duration was more prevalent among adults with IBD. In addition, the prevalence of meeting neither aerobic nor muscle-strengthening physical activity guidelines was higher among adults with IBD, which might be an indication of severity of symptoms. Although there is no current exercise recommendation to adults with IBD, mild exercise in those with mild or moderate symptoms might not worsen disease symptoms (8). Furthermore, exercise might help build muscle mass, bone density, and improve sleep quality, and its benefits outweigh the risks for almost everyone. Adults with IBD who have mild to moderate disease activity should be encouraged to consult their clinicians about their exercise engagement.
Several chronic conditions were more prevalent among adults with IBD than among those without IBD. Although few comprehensive studies of IBD comorbidities exist, the disease has been found to be associated with multiple diseases, only some of which were gastrointestinal-related (9). For example, adults with IBD are at increased risk for certain cancers and osteoporosis (7). In this study, the prevalence of having experienced serious psychological distress in the last 30 days was higher among adults with IBD. This is consistent with past research that found adults with IBD have an increased prevalence of psychological or psychosocial disorders, including depression, anxiety, and impaired social interactions (10). Psychological disorders were also predictive of poor health-related quality of life, regardless of the severity of IBD (10). The presence of certain chronic conditions in addition to IBD might impair health-related quality of life among affected persons and further complicate disease progression and care management (9).
The findings in this study are subject to at least six limitations. First, because NHIS responses are self-reported and not corroborated by medical records, they are subject to reporting bias. Second, diagnosis of Crohn’s disease and ulcerative colitis could not be assessed separately as they are combined in a single survey question of IBD. Third, questions on other chronic conditions likely to be associated with IBD, such as anemia and osteoporosis, are not asked in the NHIS. Fourth, a short-term measure of serious psychological distress (within the last 30 days) was used as a proxy measure for mental health symptoms; therefore, the prevalence of serious psychological distress among adults with IBD could be underestimated. Fifth, although the sample weights include adjustments for survey nonresponse, the potential for nonresponse bias in the IBD estimates remains, given the Sample Adult Core response rate of 54.7% for the 2 years under analysis. Finally, the NHIS survey excluded active duty military personnel and institutionalized adults; therefore, the results cannot be generalized to the entire U.S. adult population.
Understanding the extent to which adults with IBD experience comorbidities helps further elucidate the impact of IBD. Further, assessing the health-risk behaviors of persons with IBD might aid in identifying opportunities to improve their overall health, quality of life, and disease management. Given the disease’s complexity and the effects of chronic conditions and symptoms, optimal IBD care might require a multidisciplinary approach that includes gastroenterologists, preventive medicine specialists, and other medical practitioners.
Conflict of Interest
No conflicts of interest were reported.
Corresponding author: Fang Xu, firstname.lastname@example.org, 770-488-4563.
§ Cigarette smoking status was defined as current, former, or never smoker. Current smokers reported having smoked ≥100 cigarettes in their lifetime and currently smoking cigarettes some days or every day. Former smokers reported having smoked ≥100 cigarettes in their lifetime but were not current smokers at the time of the survey. Never smokers reported they had not smoked ≥100 cigarettes in their lifetime. Binge drinking was defined as ≥12 heavy drinking days (five or more alcoholic drinks for men and four or more alcoholic drinks for women) in the past year. BMI (kg/m2) was categorized as underweight (<18.5), normal weight (≥18.5 and <25.0), overweight (≥25.0 and <30.0), or obese (≥30.0). The definition of physical activity categories followed the 2008 Physical Activity Guidelines for Americans (https://health.gov/paguidelines/pdf/paguide.pdf). Both aerobic and muscle-strengthening guidelines are met if participants reported ≥150 minutes of moderate or ≥75 minutes of vigorous equivalent aerobic activity per week and muscle strengthening activities on ≥2 days per week. Short sleep duration was defined as reporting <7 hours of sleep, on average, in a 24-hour period.
¶ Serious psychological distress is based on responses to six questions that ask how often a respondent experienced certain symptoms (feeling so sad nothing could cheer you up; nervous; restless or fidgety; hopeless; that everything was an effort; or worthless) of psychological distress during the past 30 days. The response codes (0–4) of the six items for each person are summed to yield a scale with a 0–24 range. A value of ≥13 for this scale is used here to define serious psychological distress.
** Cardiovascular disease included a history of any of the following conditions: coronary heart disease, angina, myocardial infarction, stroke, or any heart disease. Respiratory disease included a history of any of the following conditions: emphysema, chronic bronchitis, chronic obstructive pulmonary disease, or asthma. Cancer included cancer or a malignancy of any kind. Diabetes was defined as an affirmative response to the question “Other than during pregnancy, have you ever been told by a doctor or other health professional that you have diabetes or sugar diabetes?” Arthritis was defined as an affirmative response to the question “Have you ever been told by a doctor or other health professional that you have some form of arthritis, rheumatoid arthritis, gout, lupus, or fibromyalgia?” Weak or failing kidneys was defined as an affirmative response to the question “During the past 12 months, have you been told by a doctor or other health professional that you had weak or failing kidneys? Do not include kidney stones, bladder infections or incontinence.” Any liver condition was defined as an affirmative response to the question “During the past 12 months, have you been told by a doctor or other health professional that you had any kind of liver condition?” Ulcer was defined as an affirmative response to the question “Have you ever been told by a doctor or other health professional that you had an ulcer?”
†† The relative standard error is equal to the standard error divided by the estimate, then multiplied by 100.
§§ Age-adjusted prevalence analysis used the projected 2000 U.S. population distribution #8 (18–24 years, 25–44 years, 45–64 years, and ≥65 years). https://www.cdc.gov/nchs/data/statnt/statnt20.pdf.
- Dahlhamer JM, Zammitti EP, Ward BW, Wheaton AG, Croft JB. Prevalence of inflammatory bowel disease among adults aged ≥18 years—United States, 2015. MMWR Morb Mortal Wkly Rep 2016;65:1166–9. CrossRef PubMed
- Long MD, Hutfless S, Kappelman MD, et al. Challenges in designing a national surveillance program for inflammatory bowel disease in the United States. Inflamm Bowel Dis 2014;20:398–415.CrossRef PubMed
- Ghosh S, Mitchell R. Impact of inflammatory bowel disease on quality of life: results of the European Federation of Crohn’s and Ulcerative Colitis Associations (EFCCA) patient survey. J Crohn’s Colitis 2007;1:10–20. CrossRef PubMed
- Kappelman MD, Moore KR, Allen JK, Cook SF. Recent trends in the prevalence of Crohn’s disease and ulcerative colitis in a commercially insured US population. Dig Dis Sci 2013;58:519–25.CrossRef PubMed
- Longobardi T, Jacobs P, Bernstein CN. Work losses related to inflammatory bowel disease in the United States: results from the National Health Interview Survey. Am J Gastroenterol 2003;98:1064–72. CrossRef PubMed
- Sonnenberg A, Genta RM. Geographic distributions of microscopic colitis and inflammatory bowel disease in the United States. Inflamm Bowel Dis 2012;18:2288–93. CrossRef PubMed
- Farraye FA, Melmed GY, Lichtenstein GR, Kane SV. ACG clinical guideline: preventive care in inflammatory bowel disease. Am J Gastroenterol 2017;112:241–58. CrossRef PubMed
- Engels M, Cross RK, Long MD. Exercise in patients with inflammatory bowel diseases: current perspectives. Clin Exp Gastroenterol 2017;11:1–11. CrossRef PubMed
- Román ALS, Muñoz F. Comorbidity in inflammatory bowel disease. World J Gastroenterol 2011;17:2723–33. CrossRef PubMed
- Guthrie E, Jackson J, Shaffer J, Thompson D, Tomenson B, Creed F. Psychological disorder and severity of inflammatory bowel disease predict health-related quality of life in ulcerative colitis and Crohn’s disease. Am J Gastroenterol 2002;97:1994–9. CrossRef PubMed
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