World Sepsis Day 2017
2017 marks 15 years since the creation of the Surviving Sepsis Campaign, 10 years of the Sepsis Alliance and 5 years of World Sepsis Day, held annually on 13th September.
BioMed Central journals Critical Care, Journal of Intensive Care, Scandinavian Journal of Trauma Resuscitation and Emergency Medicine, Antimicrobial Resistance & Infection Control, Annals of Clinical Microbiology and Antimicrobials, Microbiome, Burns & Trauma, BMC Pediatrics, Military Medical Research and BMC Infectious Diseases are all leading the way in making sepsis research available to a global audience.
To celebrate all that has been achieved in improving awareness, diagnosis and treatment of sepsis in this time, we present you with a collection of research articles, reviews, commentaries and editorials important to furthering sepsis research.
You can also read our recent blog post by Marijke Vroomen Durning of the Sepsis Alliance:
Sepsis Awareness Month – Suspect sepsis. Save lives.
BioMed Central journals Critical Care, Journal of Intensive Care, Scandinavian Journal of Trauma Resuscitation and Emergency Medicine, Antimicrobial Resistance & Infection Control, Annals of Clinical Microbiology and Antimicrobials, Microbiome, Burns & Trauma, BMC Pediatrics, Military Medical Research and BMC Infectious Diseases are all leading the way in making sepsis research available to a global audience.
To celebrate all that has been achieved in improving awareness, diagnosis and treatment of sepsis in this time, we present you with a collection of research articles, reviews, commentaries and editorials important to furthering sepsis research.
You can also read our recent blog post by Marijke Vroomen Durning of the Sepsis Alliance:
Sepsis Awareness Month – Suspect sepsis. Save lives.
- REVIEW
Incidence, prevalence, and management of MRSA bacteremia across patient populations—a review of recent developments in MRSA management and treatment
Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause meta...Critical Care 2017 21:211Published on: 14 August 2017 - RESEARCH ARTICLE
Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical int...BMC Infectious Diseases 2017 17:554Published on: 9 August 2017 - REVIEW
Sepsis in the burn patient: a different problem than sepsis in the general population
Sepsis has recently been defined as “life-threatening organ dysfunction caused by a dysregulated host response to infection”. A great amount of effort has been made to develop early treatments for sepsis throu...Burns & Trauma 2017 5:23Published on: 8 August 2017 - REVIEW
Update on pediatric sepsis: a review
Sepsis is one of the leading causes of mortality among children worldwide. Unfortunately, however, reliable evidence was insufficient in pediatric sepsis and many aspects in clinical practice actually depend o...Journal of Intensive Care 2017 5:47Published on: 20 July 2017 - RESEARCH
Longitudinal development of the gut microbiome and metabolome in preterm neonates with late onset sepsis and healthy controls
Late onset sepsis (LOS) in preterm infants is associated with considerable morbidity and mortality. While studies have implicated gut bacteria in the aetiology of the disease, functional analysis and mechanist...Microbiome 2017 5:75Published on: 12 July 2017 - RESEARCH
Unexpected intensive care transfer of admitted patients with severe sepsis
Patients with severe sepsis generally respond well to initial therapy administered in the emergency department (ED), but a subset later decompensate and require unexpected transfer to the intensive care unit (...Journal of Intensive Care 2017 5:43Published on: 12 July 2017 - RESEARCH ARTICLE
Incidence, clinical features, and implications on outcomes of neonatal late-onset sepsis with concurrent infectious focus
Neonatal bloodstream infection (BSI) is the most important cause of morbidity and mortality in the neonatal intensive care unit (NICU). Although most neonatal BSIs are primary bacteremia, some are associated w...BMC Infectious Diseases 2017 17:465Published on: 3 July 2017 - RESEARCH
Emerging antimicrobial resistance in early and late-onset neonatal sepsis
Compared to developed countries, the use of antimicrobials in Egypt is less regulated and is available over the counter without the need for prescriptions. The impact of such policy on antimicrobial resistance...Antimicrobial Resistance & Infection Control 2017 6:63Published on: 13 June 2017 - RESEARCH
Prevalence of antimicrobial resistant pathogens from blood cultures: results from a laboratory based nationwide surveillance in Ghana
Blood stream infections (BSI) are critical medical conditions with high morbidity and mortality. There is paucity of information on BSI from surveillance studies in Ghana.Antimicrobial Resistance & Infection Control 2017 6:64Published on: 13 June 2017 - ORIGINAL RESEARCH
Poor performance of quick-SOFA (qSOFA) score in predicting severe sepsis and mortality – a prospective study of patients admitted with infection to the emergency department
We aimed to evaluate the clinical usefulness of qSOFA as a risk stratification tool for patients admitted with infection compared to traditional SIRS criteria or our triage system; the Rapid Emergency Triage a...Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017 25:56Published on: 9 June 2017 - EDITORIAL
Fourth Surviving Sepsis Campaign’s hemodynamic recommendations: a step forward or a return to chaos?
Critical Care 2017 21:133Published on: 30 May 2017 - RESEARCH ARTICLE
Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis
A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis...BMC Infectious Diseases 2017 17:302Published on: 24 April 2017 - RESEARCH
Retinal arterial blood flow and retinal changes in patients with sepsis: preliminary study using fluorescein angiography
Although tissue perfusion is often decreased in patients with sepsis, the relationship between macrohemodynamics and microcirculatory blood flow is poorly understood. We hypothesized that alterations in retina...Critical Care 2017 21:86Published on: 10 April 2017 - REVIEW
The efficacy and safety of tigecycline for the treatment of bloodstream infections: a systematic review and meta-analysis
Patients with bloodstream infections (BSI) are associated with high mortality rates. Due to tigecycline has shown excellent in vitro activity against most pathogens, tigecycline is selected as one of the candi...Annals of Clinical Microbiology and Antimicrobials 2017 16:24Published on: 5 April 2017 - RESEARCH ARTICLE
Prevention of neonatal late-onset sepsis: a randomised controlled trial
Late-onset sepsis (LOS), defined as sepsis occurring after 48 h of age causes substantial mortality and morbidity in very low birth weight infants. Risk factors for LOS include immaturity, intravascular cathet...BMC Pediatrics 2017 17:98Published on: 4 April 2017 - CASE REPORT
Citrobacter braakii bacteremia-induced septic shock after colonoscopy preparation with polyethylene glycol in a critically ill patient: a case report
Polyethylene glycol (PEG) is widely used for bowel cleaning in preparation for colonoscopy because of its safety. Septic shock after PEG preparation is an extremely rare complication. Herein, we describe a cas...Annals of Clinical Microbiology and Antimicrobials 2017 16:22Published on: 4 April 2017 - RESEARCH
Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland
Newborns are a population in which antibiotic consumption is extremely high. Targeted antibiotic therapy should help to reduce antibiotics consumption. The aim of this study was an assessment of antibiotic usa...Annals of Clinical Microbiology and Antimicrobials 2017 16:20Published on: 31 March 2017 - RESEARCH
Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA...Critical Care 2017 21:73Published on: 26 March 2017 - REVIEW
The haemodynamic dilemma in emergency care: Is fluid responsiveness the answer? A systematic review
Fluid therapy is a common and crucial treatment in the emergency department (ED). While fluid responsiveness seems to be a promising method to titrate fluid therapy, the evidence for its value in ED is unclear...Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017 25:25Published on: 6 March 2017 - REVIEW
Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis
Despite recent advances in medical care, mortality due to sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains high. Fluid resuscitation and vasopr...Journal of Intensive Care 2017 5:22Published on: 3 March 2017 - ORIGINAL RESEARCH
Presentations of adult septic patients in the prehospital setting as recorded by emergency medical services: a mixed methods analysis
Current sepsis screening tools rely on vital parameters which are, however, normal in one third of patients with serious infections. Therefore, there is a need to include other variables than vital parameters ...Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2017 25:23Published on: 3 March 2017 - REVIEW
Role of the IL-33-ST2 axis in sepsis
Sepsis remains a major clinical problem with high morbidity and mortality. As new inflammatory mediators are characterized, it is important to understand their roles in sepsis. Interleukin 33 (IL-33) is a rece...Military Medical Research 2017 4:3Published on: 2 February 2017 - RESEARCH
Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival
Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of vital signs and detection of organ failure during triage in the emergency room. However, there is less...Critical Care 2016 20:244Published on: 5 August 2016 - COMMENTARYCritical Care 2016 20:210Published on: 17 July 2016
- RESEARCH
Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes
Sepsis is the focus of national quality improvement programs and a recent public reporting measure from the Centers for Medicare and Medicaid Services. However, diagnosing sepsis requires interpreting nonspeci...Critical Care 2016 20:89Published on: 6 April 2016
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