Using Next-Generation Sequencing to Explore Genetics and Race in the High School Classroom. - PubMed - NCBI

Using Next-Generation Sequencing to Explore Genetics and Race in the High School Classroom. - PubMed - NCBI

CBE Life Sci Educ. 2017 Summer;16(2). pii: ar22. doi: 10.1187/cbe.16-09-0281.

Using Next-Generation Sequencing to Explore Genetics and Race in the High School Classroom.

Yang X1, Hartman MR1, Harrington KT1, Etson CM1, Fierman MB1, Slonim DK2, Walt DR3.

Author information

Abstract

With the development of new sequencing and bioinformatics technologies, concepts relating to personal genomics play an increasingly important role in our society. To promote interest and understanding of sequencing and bioinformatics in the high school classroom, we developed and implemented a laboratory-based teaching module called "The Genetics of Race." This module uses the topic of race to engage students with sequencing and genetics. In the experimental portion of this module, students isolate their own mitochondrial DNA using standard biotechnology techniques and collect next-generation sequencing data to determine which of their classmates are most and least genetically similar to themselves. We evaluated the efficacy of this module by administering a pretest/posttest evaluation to measure student knowledge related to sequencing and bioinformatics, and we also conducted a survey at the conclusion of the module to assess student attitudes. Upon completion of our Genetics of Race module, students demonstrated significant learning gains, with lower-performing students obtaining the highest gains, and developed more positive attitudes toward scientific research.

© 2017 X. Yang, M. R. Hartman, et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

PMID:

 

28408407

 

DOI:

 

10.1187/cbe.16-09-0281

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Last Posted: Apr 20, 2017

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