Using the 21-gene assay from core needle biopsies to choose neoadjuvant therapy for breast cancer: A multicenter trial. - PubMed - NCBI
J Surg Oncol. 2017 Apr 13. doi: 10.1002/jso.24610. [Epub ahead of print]
Using the 21-gene assay from core needle biopsies to choose neoadjuvant therapy for breast cancer: A multicenter trial.
Bear HD1,
Wan W1,
Robidoux A2,
Rubin P3,
Limentani S4,
White RL Jr4,
Granfortuna J3,
Hopkins JO5,
Oldham D6,
Rodriguez A7,
Sing AP8.
Abstract
OBJECTIVE:
We hypothesized that the Oncotype Dx® 21-gene Recurrence Score (RS) could guide neoadjuvant systemic therapy (NST) to facilitate breast conserving surgery (BCS) for hormone receptor positive (HR+) breast cancers. METHODS:
This study enrolled patients with HR+, HER2-negative, invasive breast cancers not suitable for BCS (size ≥ 2 cm). Core needle biopsy blocks were tested. For tumors with RS < 11, patients received hormonal therapy (NHT); patients with RS > 25 tumors received chemotherapy (NCT); patients with RS 11-25 were randomized to NHT or NCT. Primary endpoint was whether 1/3 or more of randomized patients refused assigned treatment. RESULTS:
Sixty-four patients were enrolled. Of 33 patients with RS 11-25, 5 (15%) refused assignment to NCT. This was significantly lower than the 33% target (binomial test, P = 0.0292). Results for clinical outcomes (according to treatment received for 55 subjects) included successful BCS for 75% of tumors with RS < 11 receiving NHT, 72% for RS 11-25 receiving NHT, 64% for RS 11-25 receiving NCT, and 57% for RS > 25 receiving NCT. CONCLUSIONS:
Using the RS to guide NST is feasible. These results suggest that for patients with RS < 25 NHT is a potentially effective strategy. © 2017 Wiley Periodicals, Inc.
KEYWORDS:
breast cancer; chemotherapy; gene expression; hormonal therapy; neoadjuvant
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