Rasagiline-induced severe recurrent hypoglycemia in a young woman without diabetes: a case report | Journal of Medical Case Reports | Full Text

Rasagiline-induced severe recurrent hypoglycemia in a young woman without diabetes: a case report | Journal of Medical Case Reports | Full Text



Journal of Medical Case Reports

Rasagiline-induced severe recurrent hypoglycemia in a young woman without diabetes: a case report

• Fawzi A. Bachet IbrahimEmail author,
• Fauzia Rashid,
• Azza A. Bin Hussain,
• Fatheya Alawadi and
• A. Bashier

Journal of Medical Case Reports201711:29

DOI: 10.1186/s13256-017-1202-x

©  The Author(s). 2017

Received: 8 February 2016

Accepted: 6 January 2017

Published: 2 February 2017

Open Peer Review reports

Abstract

Background

We report a case of a patient with recurrent severe hypoglycemia after initiating the drug rasagiline (Azilect) for Parkinson disease.

Case presentation

A 25-year-old Emirati woman who had been diagnosed with Parkinson disease due to a genetic mutation since the age of 18 years presented to our hospital. She had been treated with a rotigotine patch 2 mg per day along with carbidopa + levodopa + entacapone 25 mg/100 mg/200 mg (Stalevo) over these years. Recently, her Stalevo had been changed to rasagiline (a monoamine oxidase B inhibitor). Soon after this change, she started experiencing recurrent documented severe hypoglycemia requiring hospitalization. Her hypoglycemic symptoms completely disappeared after 5–7 days of drug withdrawal. Despite detailed evaluation, no other causal relationship was documented except for rasagiline.

Conclusions

To the best of our knowledge, this case report documents an unknown association between rasagiline and hypoglycemia.

Keywords

Rasagiline Parkinson disease MAO inhibitor Hypoglycemia Diabetes Case report SSRI