Ivermectin to reduce malaria transmission
Hundreds of millions of people have received ivermectin every year in campaigns against onchocerciasis and lymphatic filariasis with excellent safety profile. It is also an endectocide, a drug capable of killing mosquitoes feeding on treated subjects.
In the face of the challenges posed by insecticide resistance and residual transmission, mass drug administration of endectocides holds potential as a complementary strategy for malaria elimination.
Mounting evidence suggests that mass-treatment of humans (or their livestock) with ivermectin can reduce vector survival and help reduce malaria transmission. There are however numerous knowledge gaps regarding the appropriate dosing, trial design and regulatory pathway for such a novel approach.
This ‘Ivermectin to reduce malaria transmission’ thematic series in the Malaria Journal aims at providing a comprehensive assessment and factors to consider in adapting this tool for a potential new indication.
This series of articles has not been sponsored. All articles in this series have undergone the journal’s standard peer-review process and each article can also be found individually in the journal.
- COMMENTARY
Upon entering an age of global ivermectin-based integrated mass drug administration for neglected tropical diseases and malaria
Ivermectin mass drug administration (MDA) in humans to reduce malaria vectors is yet another use for this remarkable medicine whose discoverers shared the 2015 Nobel Prize in Medicine with the discoverer of ar...Malaria Journal 2017 16:168Published on: 24 April 2017 - REVIEW
Ivermectin to reduce malaria transmission II. Considerations regarding clinical development pathway
The development of ivermectin as a complementary vector control tool will require good quality evidence. This paper reviews the different eco-epidemiological contexts in which mass drug administration with ive...Malaria Journal 2017 16:166Published on: 24 April 2017 - REVIEW
Ivermectin to reduce malaria transmission III. Considerations regarding regulatory and policy pathways
Vector control is a task previously relegated to products that (a) kill the mosquitoes directly at different stages (insecticides, larvicides, baited traps), or (b) avoid/reduce human-mosquito contact (bed net...Malaria Journal 2017 16:162Published on: 24 April 2017 - REVIEW
Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety
Ivermectin is an endectocide that has been used broadly in single dose community campaigns for the control of onchocerciasis and lymphatic filariasis for more than 30 years. There is now interest in the potent...Malaria Journal 2017 16:161Published on: 24 April 2017
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