HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.

Vince N1, Bashirova AA1, Lied A2, Gao X3, Dorrell L4, McLaren PJ5, Fellay J5, Carrington M1.

Author information

Abstract

A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.

Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

KEYWORDS:

HESN; HIV-1; HLA; KIR; hemophilia

PMID:: 24719475
PMCID:: PMC4215081
DOI:: 10.1093/infdis/jiu214

[Indexed for MEDLINE]

Free PMC Article

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