Whole-Genome Sequencing of a Healthy Aging Cohort. - PubMed - NCBI

Whole-Genome Sequencing of a Healthy Aging Cohort. - PubMed - NCBI

Cell. 2016 May 5;165(4):1002-11. doi: 10.1016/j.cell.2016.03.022. Epub 2016 Apr 21.

Whole-Genome Sequencing of a Healthy Aging Cohort.

Erikson GA1, Bodian DL2, Rueda M1, Molparia B1, Scott ER1, Scott-Van Zeeland AA3, Topol SE1, Wineinger NE1, Niederhuber JE4, Topol EJ5, Torkamani A6.

Author information

Abstract

Studies of long-lived individuals have revealed few genetic mechanisms for protection against age-associated disease. Therefore, we pursued genome sequencing of a related phenotype-healthy aging-to understand the genetics of disease-free aging without medical intervention. In contrast with studies of exceptional longevity, usually focused on centenarians, healthy aging is not associated with known longevity variants, but is associated with reduced genetic susceptibility to Alzheimer and coronary artery disease. Additionally, healthy aging is not associated with a decreased rate of rare pathogenic variants, potentially indicating the presence of disease-resistance factors. In keeping with this possibility, we identify suggestive common and rare variant genetic associations implying that protection against cognitive decline is a genetic component of healthy aging. These findings, based on a relatively small cohort, require independent replication. Overall, our results suggest healthy aging is an overlapping but distinct phenotype from exceptional longevity that may be enriched with disease-protective genetic factors. VIDEO ABSTRACT.

Copyright © 2016 Elsevier Inc. All rights reserved.

PMID:

 

27114037

 

PMCID:

 

PMC4860090

 [Available on 2017-05-05]

 

DOI:

 

10.1016/j.cell.2016.03.022

[Indexed for MEDLINE]

Last Posted: Mar 16, 2017

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