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Featured article: Modelling Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia, currently affecting approximately 44 million people world-wide. This model of partial differential equations is used to simulate the effect of drugs currently undergoing clinical trials and to suggest a combination of therapies capable of slowing the progression of AD.

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1. RESEARCH ARTICLE

   A computational method for the investigation of multistable systems and its application to genetic switches

   Miriam Leon, Mae L. Woods, Alex J. H. Fedorec and Chris P. Barnes

   Published on: 7 December 2016
2. RESEARCH

   A physarum-inspired prize-collecting steiner tree approach to identify subnetworks for drug repositioning

   Yahui Sun, Pathima Nusrath Hameed, Karin Verspoor and Saman Halgamuge

   Published on: 5 December 2016
3. RESEARCH

   Small RNA profiles in soybean primary root tips under water deficit

   Yun Zheng, Vandana Hivrale, Xiaotuo Zhang, Babu Valliyodan, Christine Lelandais-Brière, Andrew D. Farmer, Gregory D. May, Martin Crespi, Henry T. Nguyen and Ramanjulu Sunkar

   Published on: 5 December 2016
4. RESEARCH

   Superpixel-based segmentation of muscle fibers in multi-channel microscopy

   Binh P. Nguyen, Hans Heemskerk, Peter T. C. So and Lisa Tucker-Kellogg

   Published on: 5 December 2016
5. RESEARCH

   Integrated single cell data analysis reveals cell specific networks and novel coactivation markers

   Shila Ghazanfar, Adam J. Bisogni, John T. Ormerod, David M. Lin and Jean Y. H. Yang

   Published on: 5 December 2016

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