Scientists ID Key Fetal Cells Vulnerable to Zika

Lab study suggests possible mechanism for birth defects to develop

By Robert Preidt

Thursday, September 29, 2016

THURSDAY, Sept. 29, 2016 (HealthDay News) -- The devastating mosquito-borne Zika virus can infect cells that play a role in skull development, a new study finds.

The findings may help explain why Zika infection during pregnancy can lead to babies with smaller-than-normal heads and brains, a birth defect called microcephaly.

In laboratory experiments, the Stanford University researchers discovered that cranial neural crest cells are vulnerable to Zika. These cells form the majority of bone and cartilage of the head and communicate with the developing brain.

"Our in vitro studies raise an intriguing possibility that the Zika virus can infect human cranial neural crest cells in the developing embryo, which in turn could influence brain development," said co-senior author Joanna Wysocka, a chemical and systems biologist at Stanford.

Neural crest cell formation occurs during the first trimester, "which intriguingly has been correlated with poor birth outcomes in Zika-infected mothers," she said in a Stanford news release.

The study was published Sept. 29 in the journal Cell Host & Microbe.

Although the findings offer leads for future research, the study doesn't provide direct proof that Zika infects cranial neural crest cells in animals or humans. Nor does it offer evidence that such infection would be sufficient to result in microcephaly, the researchers emphasized.

SOURCE: Stanford University School of Medicine, news release, Sept. 29, 2016

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