Added text to state that an analysis of the Childhood Cancer Survivor Study (CCSS) and Surveillance, Epidemiology, and End Results (SEER) study evaluating conditional survival demonstrated a subsequent 5-year survival rate of 92% or higher among most diagnoses at 5 years, 10 years, 15 years, and 20 years. Among those who had survived at least 5 years from diagnosis, the probability of all-cause mortality in the next 10 years was 8.8% in the CCSS and 10.6% in the SEER study, with neoplasms accounting for cause of death in approximately 75% of survivors (cited Mertens et al. as reference 22).
Added text about a collaborative study of North American and European pediatric cancer cohorts that evaluated the hazard ratio for clinical heart failure through age 40 years for doses of daunorubicin and doxorubicin (cited Feijen et al. as reference 28).
Added text to state that while these data suggest that dexrazoxane does protect the heart, there are not yet long-term data showing the impact of dexrazoxane on cardiac health (cited van Dalen et al. as reference 29).
Added text about the possible association between dexrazoxane and increased risk of second cancers (cited Chow et al. as reference 36).
Added text to state that radiation dose to specific subvolumes of the brain, including the temporal lobes and hippocampi, have been shown to significantly impact longitudinal intelligence quotients and academic achievement scores among children treated with craniospinal irradiation for medulloblastoma (cited Merchant et al. as reference 17).
Added text about a cross-sectional study that evaluated neurologic morbidity and quality of life in 162 survivors of childhood acute lymphoblastic leukemia (ALL).
Added text about a CCSS study that evaluated psychological and neurocognitive function in 2,589 long-term cancer survivors who were diagnosed during adolescence and young adulthood (cited Prasad et al. as reference 86).
Added text about a study from the CCSS that evaluated the incidence and risk of late-occurring intestinal obstruction requiring surgery in 12,316 5-year survivors and 4,023 siblings (cited Madenci et al. as reference 36 and level of evidence 3iiiC).
Added text to state that clinicians should consider and encourage the administration of inactivated vaccines and vaccines made of purified antigens, bacterial components, or genetically engineered recombinant antigens in all cancer and transplant survivors according to recommended doses and schedules (cited National Center for Immunization and Respiratory Diseases, Bridges et al., and Rubin et al. as references 6, 7, and 8, respectively).
Added text about a longitudinal study that evaluated the magnitude and trajectory of pulmonary dysfunction among 121 childhood cancer survivors treated with potentially pulmonary-toxic therapy (cited Armenian et al. as reference 4).
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