Genomics|HuGENet

Genomics|HuGENet

Epidemiology: Big Data and Precision Medicine
Epidemiology is the basic science of public health genomics, concerned with understanding how human and pathogen genomic variation affects the distribution of disease in populations. Big data and precision medicine are affecting the future of the field.

Epidemiology

Epidemiology is the basic science of public health genomics, concerned with understanding how human and pathogen genomic variation affects the distribution of disease in populations .

The Office of Public Health Genomics tracks epidemiologic study results in ourweekly horizon scan and Advanced Molecular Detection Clips and deposits relevant publications in the Public Health Genomics Knowledge Base.

In addition, the Office  established the Human Genome Epidemiology Network (HuGENet) to help translate human genetic research findings into opportunities for preventive medicine and public health. For more than a decade, HuGENet has advanced a population perspective on human genetic variation in health and disease through data synthesis, interpretation, and dissemination.

To learn more about Human Genome Epidemiology resources, please click on the links below.

NEW: Planning for the Future of Epidemiology in the Era of Big Data and Precision Medicine.
Khoury MJ. Am J Epidemiol. 2015 Dec 1. pii: kwv228.

NEW: Primers on -Omic Technologies for the Practice of Epidemiology, from the American Journal of Epidemiology, 2015.

• Muin J. Khoury. A Primer Series on -Omic Technologies for the Practice of Epidemiology. Am. J. Epidemiol. (2014) 180 (2): 127-128
• Viswam S. Nair, Colin C. Pritchard, Muneesh Tewari and John P. A. Ioannidis. Design and Analysis for Studying microRNAs in Human Disease: A Primer on -Omic Technologies. Am. J. Epidemiol. (2014) 180 (2): 140-152
• Ioanna Tzoulaki, Timothy M. D. Ebbels, Ana Valdes, Paul Elliott and John P. A. Ioannidis. Design and Analysis of Metabolomics Studies in Epidemiologic Research: A Primer on -Omic Technologies. Am. J. Epidemiol. (2014) 180 (2): 129-139
• Steven S. Coughlin. Toward a Road Map for Global -Omics: A Primer on -Omic Technologies.Am. J. Epidemiol. (2014) 180 (12): 1188-1195
• Harald Mischak, Elena Critselis, Samir Hanash, William M. Gallagher, Antonia Vlahou and John P. A. Ioannidis. Epidemiologic Design and Analysis for Proteomic Studies: A Primer on -Omic Technologies. Am. J. Epidemiol. (2015) 181 (9): 635-647
• Betsy Foxman and Emily T. Martin. Use of the Microbiome in the Practice of Epidemiology: A Primer on -Omic Technologies. Am. J. Epidemiol. (2015) 182 (1): 1-8

Selected CDC Articles

• Brownson Ross C et al. Charting a future for epidemiologic training. Ann Epidemiol 2015 Jun (6) 458-65
• Marrone Michael et al. Opportunities for translational epidemiology: the important role of observational studies to advance precision oncology. Cancer Epidemiol. Biomarkers Prev. 2015 Mar (3) 484-9
• Mukesh Verma et al. Epigenetic research in cancer epidemiology: Trends, opportunities, and challenges. Cancer Epidemiology Biomarkers and Prevention (2014)
• Spitz MR, Lam TK, Schully SD, Khoury MJ. The Next Generation of Large-Scale Epidemiologic Research: Implications for Training Cancer Epidemiologists. Am J Epidemiol. 2014 Sep 18. pii: kwu256.
• Transforming epidemiology for 21st century population health in the age of genomics and big data, CEBP (2013)
• Q&A: Muin Khoury on cancer epidemiology. Cancer Discov. 2014 Feb;4(2):140.
  Check out all CDC publications in epidemiology and public health genomics.

Epidemiology Resources

• HuGE Navigator
  A searchable, online knowledge base in human genome epidemiology, updated weekly from PubMed.

• Guidelines
  Published recommendations for enhancing  the reporting, synthesis, and translation of human genome epidemiology research.

• Bibliography
  Published guidelines, methods, analyses, and commentaries in human genome epidemiology.  

• Reviews
  Instructions for reading and writing HuGE Reviews.

• Case studies
  Self-guided online case studies for teaching concepts in human genome epidemiology.

• Workshops
  Agendas and summaries for past HuGENet workshops.

• Links
  Links to organizations and databases around the world.
• Advanced Molecular Detection Clips
  Links to epidemiology articles relevant to pathogen genomics
• Public Health Genomics Knowledge Base
  CDC Curated database that features epidemiologic studies of human and pathogen genomics