Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia - Volume 21, Number 7—July 2015 - Emerging Infectious Disease journal - CDC
Volume 21, Number 7—July 2015
Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia
Human adenoviruses (HAdVs) are classified into >50 types and are associated with clinical manifestations that include respiratory, gastrointestinal, ocular, genitourinary, and neurologic disease (1). HAdV infections have been estimated to cause 5%–10% of acute respiratory illnesses in children <5 years of age. Although most infections are subclinical or result in mild upper respiratory tract illnesses, HAdVs can also cause severe pneumonia. Among the HAdV types, type 7 (Ad7) has most often been associated with severe respiratory disease (2).
Recent reports have noted increased incidence of severe Ad7 disease in Asia: among the general population and pediatric inpatients in Taiwan; among persons in a military training camp in Shaanxi, China; and among those in a police training center in Kuala Lumpur, Malaysia (2–4). During January–June 2013, physicians in Singapore noted an increase in HAdV pediatric inpatients. Here we characterize the clinical and molecular epidemiology of this outbreak by reviewing data from government hospitals, the military, and a nationwide influenza-like illness (ILI) laboratory surveillance network in Singapore.
We thank the staff of all participating institutions who contributed to patient care and data collection for this analysis.
This study was supported by the Transition Award (NMRC/TA/0009/2012) grant, the Singapore National University Health System H7N9 grant (NUHSRO/2013/144/H7N9/06), and the NHG Small Innovative Grant (SIG/14015). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Dr. Ng is an Infectious Disease Consultant at Tan Tock Seng Hospital. His primary research interests are pathogen molecular epidemiology, emerging infectious diseases, and HIV.
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Suggested citation for this article: Ng OT, Thoon KC, Chua HY, Tan NWH, Chong CY, Tee NWS, et al. Severe pediatric adenovirus 7 disease in Singapore linked to recent outbreaks across Asia. Emerg Infect Dis. 2015 Jul [date cited]. http://dx.doi.org/10.3201/eid2107.141443