Ahead of Print -Outbreak of Ciprofloxacin-Resistant Shigella sonnei Associated with Travel to Vietnam, South Korea - Volume 21, Number 7—July 2015 - Emerging Infectious Disease journal - CDC

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Ahead of Print -Outbreak of Ciprofloxacin-Resistant Shigella sonnei Associated with Travel to Vietnam, South Korea - Volume 21, Number 7—July 2015 - Emerging Infectious Disease journal - CDC

Volume 21, Number 7—July 2015

Dispatch

Outbreak of Ciprofloxacin-Resistant Shigella sonnei Associated with Travel to Vietnam, South Korea

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• The Study
• Conclusions
• Suggested Citation

Figures

• Figure 1
• Figure 2

Tables

• Table

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Jin Seok Kim, Jae Joon Kim, Soo Jin Kim, Se-Eun Jeon, Ki Yeon Seo, Jun-Kil Choi, Nan-Ok Kim, Sahyun Hong, Gyung Tae Chung, Cheon-Kwon Yoo, Young-Taek Kim, Hyeng Il Cheun, Geun-Ryang Bae, Yeong-Hee Yeo, Gang-Ja Ha, Mi-Suk Choi, Shin-Jung Kang, and Junyoung Kim 

Author affiliations: Korea National Institute of Health, Cheongju-si, South Korea (J.S. Kim, S.J. Kim, S.E. Jeon, N.-O. Kim, S. Hong, G.T. Chung, C.-K. Yoo, S.-J. Kang, J. Kim); Gyeongsangnam-do Provincial Government, Changwon-si (J.J. Kim); Korea Centers for Disease Control and Prevention, Cheongju-si (K.Y. Seo, J.-K. Choi, Y.T. Kim, H.I. Cheun, G.-R. Bae); Gyeongsangnam-do Public Health and Environmental Research Institute, Changwon-si (Y.-H. Yeo, G.-J. Ha); Changnyeong Preservation of Health, Changnyeong-gun, South Korea (M.-S. Choi)

Suggested citation for this article

Abstract

We investigated an October 2014 outbreak of illness caused by Shigella sonnei in a daycare center in South Korea. The outbreak strain was resistant to extended-spectrum cephalosporins and fluoroquinolones and was traced to a child who had traveled to Vietnam. Improved hygiene and infection control practices are needed for prevention of shigellosis.

Shigella spp. are etiologic agents of gastrointestinal disease worldwide and are frequently associated with outbreaks because of their low infectious doses and person-to-person transmission (1,2). For the treatment of persons who have severe infections, fluoroquinolones are among the first-line agents for adults; additionally, oral extended-spectrum cephalosporins are used to treat young children. However, the current emergence and spread of drug resistance in Shigella strains could hinder empirical antimicrobial therapy, leading to treatment failure. S. sonnei is the most frequently isolated species among all cases of Shigella infection in industrialized countries (3), and it has become increasingly prevalent across Southeast Asia in recent decades (4). Recently, international travel to areas where the disease is highly endemic has accelerated the global spread of drug-resistant S. sonnei to nonendemic regions. Here, we describe a travel-associated outbreak of illness caused by a S. sonnei strain that was resistant to extended-spectrum cephalosporins and fluoroquinolones.

Dr Kim is a researcher at Center for Infectious Disease in the Korea National Institute of Health. His primary research interests include antimicrobial drug susceptibility and molecular epidemiology of enteric bacteria.

Acknowledgment

This work was supported by a grant from the Korea Centers for Disease Control and Prevention [4847-311-210].

References

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Figures

• Figure 1. Epidemic curve of the outbreak of illness caused by Shigella sonnei infection, by symptom onset date, South Korea, 2014. Black bar sections indicate laboratory-confirmed cases; white bar sections indicate...
• Figure 2. XbaI pulsed-field gel electrophoresis patterns of Shigella sonnei strains identified during a 2014 outbreak in South Korea and 2 isolated from samples from persons in Vietnam. The dendrogram was...

Table

• Table. Susceptibility profiles of outbreak Shigella sonnei isolate from index case-patient and Escherichia coli transconjugant strain used for testing, South Korea, 2014

Suggested citation for this article: Kim JS, Kim JJ, Kim SJ, Jeon SE, Seo KY, Choi JK, et al. Outbreak of ciprofloxacin-resistant Shigella sonnei associated with travel to Vietnam, South Korea. Emerg Infect Dis. 2015 Jul [date cited]. http://dx.doi.org/10.3201/eid2107.150363

DOI: 10.3201/eid2107.150363