Stroke: Public Health and Genomic Insights - May 7, 2015

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Stroke

Stroke: Public Health and Genomic Insights - May 7, 2015

CDC and related Info

• Stroke facts
• Stroke
• Sickle cell disease complications include stroke
• Family history and other characteristics increase risk for stroke
• Genes reported in relation to cerebrovascular accident, including genomewide association studies via theHuGE Navigator

Check out genes associated with stroke occurrence and outcomes, from the HuGE Navigator

Check out genetic conditions and tests associated with stroke, from the NIH Genetic Testing Registry

CDC stroke facts

Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants.
Malik R et al. Neurology 2015 May 1.

Tackling shared genetic underpinnings of migraine and ischemic stroke.
Debette S et al. Neurology 2015 May 1.

No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin: The PROMISe study.
Achterberg S et al. PLoS ONE 2015 (4) e0119203

Genetic factors in cerebral small vessel disease and their impact on stroke and dementia.
Haffner C et al. J. Cereb. Blood Flow Metab. 2015 Apr 22.

The association between carbohydrate-rich foods and risk of cardiovascular disease is not modified by genetic susceptibility to dyslipidemia as determined by 80 validated variants.
Sonestedt E et al. PLoS ONE 2015 (4) e0126104

Tobacco smoking strongly modifies the association of prothrombin G20210A with undetermined stroke: Consecutive survivors and population-based controls.
Krajcoviechova A et al. Atherosclerosis 2015 Apr 11. (2) 446-452

Association between the FGB gene polymorphism and ischemic stroke: a meta-analysis.
Zhang X F et al. Genet. Mol. Res. 2015 (1) 1741-7

CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction increases susceptibility to ischemic stroke.
Yi Xingyang et al. Gene 2015 Jul 1. (1) 85-9

Stroke in Children: Public Health and Genomic Insights - May 1, 2015

CDC information: Stroke in children and young adults accounts for 5 to 10% of all strokes and is among the top 10 causes of childhood death

What causes stroke in children? From the American Stroke Association

CDC information: Sickle cell disease complications include stroke

Paediatric stroke: pressing issues and promising directions.
Kirton A et al. Lancet Neurol 2015 Jan (1) 92-102

Systematic review: hereditary thrombophilia associated to pediatric strokes and cerebral palsy.
Torres VM et al. J Pediatr (Rio J) 2015 Jan-Feb (1) 22-9

Methylenetetrahydrofolate reductase gene A1298C polymorphism in pediatric stroke--case-control and family-based study.
Balcerzyk A et al. J Stroke Cerebrovasc Dis 2015 Jan (1) 61-5

Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease.
Lance EI et al. Proteomics Clin Appl 2014 Dec (11-12) 813-27

Strokes in children: a systematic review.
Gumer LB et al. Pediatr Emerg Care 2014 Sep (9) 660-4

Costs of pediatric stroke care in the United States: a systematic and contemporary review.
Ellis C et al. Expert Rev Pharmacoecon Outcomes Res 2014 Oct (5) 643-50

Stroke in sickle cell anemia patients: a need for multidisciplinary approaches.
Menaa F et al. Atherosclerosis 2013 Aug (2) 496-503

Stroke: Folates, Genetics and Public Health - March 16, 2015

Folate supplements for stroke prevention - targeted trial trumps the rest
Stampfer M et al. JAMA March 12, 2015

Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China - the CSPPT randomized clinical trial
Y H et al. JAMA, March 12, 2015

Association of reduced folate carrier-1 (RFC-1) polymorphisms with ischemic stroke and silent brain infarction.
Cho Y et al. PLoS ONE 2015 (2) e0115295

Genetic associations with plasma B12, B6, and folate levels in an ischemic stroke population from the vitamin intervention for stroke prevention (VISP) trial.
Keene KL et al. Front Public Health 2014 112

Quantitative assessment of association between rs1801133 polymorphism and susceptibility to stroke.
Zhang W et al. Cell Biochem. Biophys. 2015 Jan (1) 85-98

Signaling pathway genes for blood pressure, folate and cholesterol levels among hypertensives: an epistasis analysis.
Wei LK et al. J Hum Hypertens 2015 Feb (2) 99-104

Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population.
Zhou BS et al. Int J Mol Sci 2014 (5) 8931-40

Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
Williams SR et al. PLoS Genet. 2014 Mar (3) e1004214

Strokes in young adults: epidemiology and prevention.
Smajlovic D Vasc Health Risk Manag 2015 157-164

Cytochrome 4A11 genetic polymorphisms increase susceptibility to ischemic stroke and associate with atherothrombotic events after stroke in Chinese.
Zhang B et al. Genet Test Mol Biomarkers 2015 Mar 3.

Next generation sequencing for systematic assessment of genetics of small-vessel disease and lacunar stroke.
Bersano A et al. J Stroke Cerebrovasc Dis 2015 Feb 26.

Stroke: Genetics & Public Health - October 22, 2014

CDC Information: October 29 is World Stroke Day- Stroke is the fourth leading cause of death in the United States and is a major cause of adult disability. About 800,000 people in the United States have a stroke each year. 

CDC information: Family history and other characteristics increase risk for stroke

Am I at risk for a stroke? Family history is a risk factor for stroke, from the National Stroke Association

Did you know? More than 752 genes have been reported in relation to risk and outcomes of stroke/ cerebrovascular accident, including 44 genomewide association studies?

Did you know? About 10% of children with sickle cell disease will have a symptomatic stroke? Learn about complications of sickle cell disease and how to prevent them

Researchers discover underlying genetics, marker for stroke, cardiovascular disease, NIH News (March 2014)

Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes.
Meschia JF et al. Stroke, October 2013

A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.
Matthew Traylor mail et al. PLOS Genetics (2014)