Psychiatric Disorders: New Genomic Insights - May 4, 2015

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Psychiatric Disorders

Psychiatric Disorders: New Genomic Insights - May 4, 2015

CDC and Related Info

• Burden of mental illness
• Genes reported in relation to schizophrenia, including genomewide association studies via theHuGE Navigator

Brain disorders? Precisely.
Insel TR et al. Science2015 May 1. (6234) 499-500

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Psychiatric Genomics Consortium. Nature Neuroscience, January 19, 2015

The Psychiatric Genomics Consortium conducts mega-analyses of genome-wide genetic data for psychiatric disorders.

Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.
Neale BM, Sklar P. Curr Opin Neurobiol. 2015 Feb;30C:131-138.

Genetic determinants of depression: recent findings and future directions.
Dunn EC, et al. Harv Rev Psychiatry. 2015 Jan-Feb;23(1):1-18

Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder.
Hess JL, et al. Am J Med Genet B Neuropsychiatr Genet. 2015 Jan;168(1):14-35

Genetics of complex traits in psychiatry.
Gelernter J. Biol Psychiatry. 2015 Jan 1;77(1):36-42

Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.
Doherty JL, Owen MJ. Genome Med. 2014 Apr 28;6(4):29.

Depression: Medical Research and Genomics - November 19, 2014

Mental health: The great depression. Depression causes more disability than any other disorder. A special issue explores how science can help.
Nature, 12 November 2014 

The burden of depression: Mental health is gaining acceptance as a medical problem, but progress in finding treatments is being hampered by the stigma surrounding people's everyday experiences.
Nature editorial 12 November 2014

Medical research: If depression were cancer. Research into depression has struggled, while studies of cancer have thrived — but the balance could be shifting.
Heidi Ledford, Nature 12 November 2014

Mental health: Depression needs large human-genetics studies.
Steven Hyman. Nature, 12 November 2014

Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.
Doherty JL, et al. Genome Med. 2014 Apr 28;6(4):29.

Biomarkers in major depressive disorder: the role of mass spectrometry.
Woods AG, et al. Adv Exp Med Biol. 2014;806:545-60.

Schizophrenia: Recent Genomic Insights - September 18, 2014

CDC information: Burden of mental illness

NIMH · Schizophrenia's genetic "skyline" rising

Exploring the complex genetics of schizophrenia, by Dr. Francis Collins, NIH Director's Blog, Jan 28

Did you Know? >1500 genes have been reported in relation to risk and outcomes of schizophrenia, including >200 genomewide association studies. To find out more, visit the HuGE Navigator

Check out genetic disorders and tests associated with schizophrenia, from the NIH Genetic Testing Registry

SZGene (SchizophreniaGene) Database: Field Synopsis of Genetic Association Studies in SZ

Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies
Javier Arnedo, et al. Am J Psychiatry 2014 Sep 15

Schizophrenia 'made up of eight specific genetic disorders', Medical News Today, Sep 15

Schizophrenia is eight different diseases, not one, by Liz Szabo, USA Today, Sep 15

Schizophrenia subtypes identified by combining genetic, clinical data, Genomeweb Daily, Sep 15

National Society of Genetic Counselors blog post : Is mental illness inherited? How family history and environment impact mental health

The causes of schizophrenia, from the National Alliance on Mental Illness