Asthma Awareness: Public Health and Genomic Insights - May 26, 2015

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Asthma

Asthma Awareness: Public Health and Genomic Insights - May 26, 2015

CDC and Related Info

• May is Asthma Awareness Month
• Your personal asthma action plan
• Asthma basics, statistics and surveillance, interventions and resources
• Genes reported in relation to asthma, including genomewide association studies via theHuGE Navigator

Genetic variants in TNFa, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma.
Yucesoy B et al. J Immunotoxicol 2015 Feb 27. 1-8

Genetic association of key Th1/Th2 pathway candidate genes, IRF2, IL6, IFNGR2, STAT4 and IL4RA, with atopic asthma in the Indian population.
Kumar A et al. J. Hum. Genet. 2015 May 21.

Vitamin D metabolism genes in asthma and atopy.
Morales E et al. Mini Rev Med Chem 2015 May 18.

Effect of ADRB2 (adrenergic receptor ß2) gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial asthma.
Shah NJ et al. J Asthma 2015 May 19. 1-8

GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.
Heinonen MT et al. J. Immunol. 2015 May 11.

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.
Schedel M et al. J. Allergy Clin. Immunol. 2015 Apr 28.

Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.
Sordillo JE et al. J. Allergy Clin. Immunol. 2015 Apr 24.

Genetic variation along the histamine pathway in children with allergic vs non-allergic asthma.
Anvari S et al. Am. J. Respir. Cell Mol. Biol. 2015 Apr 24.

Asthma Awareness: Public Health and Genomic Insights - April 22, 2015

CDC information: May is Asthma Awareness Month

CDC information: Your personal asthma action plan

Pharmacogenomic test that predicts response to inhaled corticosteroids in adults with asthma likely to be cost-saving.
Wu AC et al. Pharmacogenomics 2015 Apr 16. 1-10

Asthma pharmacogenetics and the development of genetic profiles for personalized medicine.
Ortega VE et al. Pharmgenomics Pers Med 2015 9-22

Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles.
Persson H et al. J. Allergy Clin. Immunol. 2015 Apr 9.

Genomic architecture of asthma differs by sex.
Mersha TB et al. Genomics 2015 Mar 25.

Association of the glucocorticoid receptor D641V variant with steroid-resistant asthma: a case-control study.
Zhao F et al. Pharmacogenet. Genomics 2015 Mar 26.

Non-invasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma.
Yan X et al. Am. J. Respir. Crit. Care Med. 2015 Mar 12.

Prediction of chemical respiratory sensitizers using GARD, a novel in vitro assay based on a genomic biomarker signature.
Forreryd A et al. PLoS ONE 2015 (3) e0118808

Predictive genetic profiles for ß-agonist therapy in asthma. A future under construction.
Ortega VE et al. Am. J. Respir. Crit. Care Med. 2015 Mar 1. (5) 494-6

Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma.
Yucesoy Berran et al. J Immunotoxicol 2015 Feb 27. 1-8

Asthma-COPD overlap. clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease.
Christenson SA et al. Am. J. Respir. Crit. Care Med. 2015 Apr 1. (7) 758-66

Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma.
Wang Y et al. Pharmacogenomics J. 2015 Jan 20.

Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.
Gomez JL et al. J. Allergy Clin. Immunol. 2015 Jan 12.

Genome-wide association study of short-acting ß2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3.
Israel E et al. Am. J. Respir. Crit. Care Med. 2015 Mar 1. (5) 530-7

Systems biology of asthma and allergic diseases: a multiscale approach.
Bunyavanich S et al. J. Allergy Clin. Immunol. 2015 Jan (1) 31-42

Genetics of allergic diseases.
Ortiz RA et al. Immunol Allergy Clin North Am 2015 Feb (1) 19-44

Biomarkers to predict asthma in wheezing preschool children.
Bannier MA et al. Clin. Exp. Allergy 2014 Nov 20.

Asthma: Genomics & Public Health - September 4, 2014

CDC information: In most cases, we don't know what causes asthma, and we don't know how to cure it. Certain factors may make it more likely for one person to have asthma than another. If someone in your family has asthma, you are more likely to have it 

CDC information: Asthma basics, statistics and surveillance, interventions and resources

Introduction to genetics and genomics in asthma
Mathias RA. Adv Exp Med Biol. 2014;795:125-55.

Stress and asthma: Novel insights on genetic, epigenetic and immunologic mechanisms. 
Stacy L. Rosenberg. JACC, August 2014 

Did you know? More than 1000 genes and 99 genomewide association studies have been reported in relation to asthma risk and outcomes? To find out more, visit the HuGE Navigator

Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis.Smolonska J, et al. The European Respiratory Journal 2014 Jul.

A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes. 
Sharma S, et al. The Journal of Allergy and Clinical Immunology 2014 Jun 

Find out about genetic conditions and tests that have been reported in relation to asthma. Visit the NIH Genetic Testing Registry