lunes, 9 de marzo de 2015

Identification and Characterization of Multi-drug Resistant Salmone... - PubMed - NCBI

Identification and Characterization of Multi-drug Resistant Salmone... - PubMed - NCBI

 2015 Mar 2. pii: AAC.05183-14. [Epub ahead of print]

Identification and Characterization of Multi-drug Resistant Salmonella enterica serotype Albert in the United States.


Salmonella enterica is one of the most common causes of bacterial foodborne illness in the United States. Although most Salmonella infections are self-limiting, antimicrobial treatment is critical for invasive salmonellosis. Primary antimicrobial treatment options include fluoroquinolones or extended-spectrum cephalosporins and antimicrobial resistance to these drugs may complicate treatment. At present, Salmonella enterica is composed of more than 2,600 unique serotypes, which vary greatly in geographic prevalence, ecological niche, and ability to cause human disease and it is important to understand and mitigate the source of human infection, particularly when antimicrobial resistance is found. In this study, we identified and characterized 19 Salmonella enterica serotype Albert isolates from food animals, retail meat, and humans collected in the United States during 2005-2013. All 5 isolates from non-human sources were obtained from turkeys or ground turkey and epidemiologic data suggest poultry consumption or live poultry exposure as the probable source of infection. Salmonella ser. Albert also appears to be geographically localized to the Midwestern states of the U.S. All 19 isolates displayed multidrug resistance (MDR), including decreased susceptibility to fluoroquinolones and resistance to extended-spectrum cephalosporins. Turkeys are a likely source of multidrug resistant Salmonella Albert, and circulation of resistance plasmids, as opposed to expansion of a single resistant strain, is playing a role. More work is needed to understand why these resistance plasmids spread and how their presence and the serotype they reside in contribute to human disease.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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