lunes, 23 de febrero de 2015

Ahead of Print -Influenza A(H10N7) Virus in Dead Harbor Seals, Denmark - Volume 21, Number 4—April 2015 - Emerging Infectious Disease journal - CDC

full-text ►

Ahead of Print -Influenza A(H10N7) Virus in Dead Harbor Seals, Denmark - Volume 21, Number 4—April 2015 - Emerging Infectious Disease journal - CDC

CDC. Centers for Disease Control and Prevention. CDC 24/7: Saving Lives. Protecting People.

Volume 21, Number 4—April 2015


Influenza A(H10N7) Virus in Dead Harbor Seals, Denmark

Jesper S. KrogComments to Author , Mette S. Hansen, Elisabeth Holm, Charlotte K. Hjulsager, Mariann Chriél, Karl Pedersen, Lars O. Andresen, Morten Abildstrøm, Trine H. Jensen, and Lars E. Larsen
Author affiliations: Technical University of Denmark, Frederiksberg, Denmark (J.S. Krog, M.S. Hansen, E. Holm, C.K. Hjulsager, M. Chriél, K. Pedersen, L.O. Andresen, L.E. Larsen)Anholt Gartneri & Naturpleje, Anholt, Denmark (M. Abildstrøm)Aalborg Zoo/Aalborg University, Aalborg, Denmark (T.H. Jensen)


Since April 2014, an outbreak of influenza in harbor seals has been ongoing in northern Europe. In Denmark during June–August, 152 harbor seals on the island of Anholt were found dead from severe pneumonia. We detected influenza A(H10N7) virus in 2 of 4 seals examined.
Influenza A virus is widespread and affects a wide range of species, including humans (1). Waterfowl are considered the natural reservoir for most subtypes of influenza A virus, and most mammalian-adapted viruses initially originated in interspecies transmission from aquatic birds (2). Avian influenza A virus (AIV) replicates primarily in the intestinal tract of birds and is transmitted mainly through the fecal–oral route (1). Pinnipeds (e.g., seals) share the same shoreline habitats as many waterfowl species and therefore can be exposed to AIV. Several instances of interspecies transmission between birds and harbor seals (Phoca vitulina) with AIV subtypes H7N7, H4N5, H4N6, H3N8, and H3N3 have been reported in the United States, and antibodies against a wide range of subtypes have been identified in Europe, Asia, and South America (reviewed by White [3]). Human infections with seal influenza A virus have occasionally been reported (3). More recently, A(H1N1)pdm09 virus was isolated from elephant seals (Mirounga angustirostris) off the central coast of California, USA (4). To our knowledge, AIV in harbor seals off the coast of northern Europe was first reported in April 2014 (5).

Dr. Krog is a molecular biologist at the National Veterinary Institute. His primary research focus is national surveillance of avian and swine influenza A virus and other zoonotic viruses.


We thank Ivar Høst for submitting the material; Y.M Deng and P. Iannello for contributing the hemagglutinin sequence EPI339225; R. Bodewes and colleagues for contributing EPI544356 and EPI544357; and S. Zohari and colleagues for EPI545212, EPI545213, EPI547696, and EPI547697 to the Global Initiative on Sharing All Influenza Data EpiFlu database.
Surveillance of diseases in wildlife is financed by the Danish Forest and Nature Agency, project no. NST-410239.


  1. Reperant LARimmelzwaan GFKuiken TAvian influenza viruses in mammals. Rev Sci Tech2009;28:13759 .PubMed
  2. Harder TCSiebert UWohlsein PVahlenkamp TInfluenza A virus infections in marine mammals and terrestrial carnivores. Berl Munch Tierarztl Wochenschr2013;126:5008 .PubMed
  3. White VC. A review of influenza viruses in seals and the implications for public health. US Army Med Dep J. 2013:45–50. PMID: 23277445
  4. Goldstein TMena IAnthony SJMedina RRobinson PWGreig DJPandemic H1N1 influenza isolated from free-ranging northern elephant seals in 2010 off the central California coast. PLoS ONE2013;8:e62259DOIPubMed
  5. Zohari SNeimanis AHärkönen TMoraeus CValarcher JFAvian influenza A (H10N7) virus involvement in mass mortality of harbour seals (Phoca vitulina) in Sweden, March through October 2014. Euro Surveill2014;19:20967 .PubMed
  6. MacDonald DWGilcheust EWDipetalonema spirocauda and Pseudomonas aeruginosa infection in a harbor seal (Phoca vitulina). Can Vet J.1969;10:2201 .PubMed
  7. Trebbien RBragstad KLarsen LENielsen JBøtner AHeegaard PMHGenetic and biological characterisation of an avian-like H1N2 swine influenza virus generated by reassortment of circulating avian-like H1N1 and H3N2 subtypes in Denmark. Virol J2013;10:290DOIPubMed
  8. Barrett TVisser IKGMamaev LGoatley Lvan Bressem MFOsterhaus ADMEDolphin and porpoise morbilliviruses are genetically distinct from phocine distemper virus. Virology1993;193:10102DOIPubMed
  9. Arzey GGKirkland PDArzey KEFrost MMaywood PCanaty SInfluenza virus A (H10N7) in chickens and poultry abbattoir workers, Australia.Emerg Infect Dis2012;18:8146DOIPubMed
  10. Zohari SMetreveli GKiss IBelák SBerg MFull genome comparison and characterization of avian H10 viruses with different pathogenicity in mink (Mustela vison) reveals genetic and functional differences in the non-structural gene. Virol J2010;7:145DOIPubMed
  11. Callan RJEarly GKida HHinshaw VSThe appearance of H3 influenza viruses in seals. J Gen Virol1995;76:199203DOIPubMed
  12. Hinshaw VSBean WJWebster RGRehg JEFiorelli PEarly GAre seals frequently infected with avian influenza viruses? J Virol1984;51:8635.PubMed
  13. Lang GGagnon AGeraci JRIsolation of an influenza A virus from seals. Arch Virol1981;68:18995DOIPubMed
  14. Webster RGHinshaw VSBean WJvan Wyke KLGeraci JRSt Aubin DJCharacterization of an influenza A virus from seals. Virology.1981;113:71224DOIPubMed
  15. Wood GWBanks JStrong IParsons GAlexander DJAn avian influenza virus of H10 subtype that is highly pathogenic for chickens, but lacks multiple basic amino acids at the haemagglutinin cleavage site. Avian Pathol1996;25:799806DOIPubMed



Suggested citation for this article: Krog JS, Hansen MS, Holm E, Hjulsager CK, Chriél M, Pedersen K, et al. Influenza A(H10N7) virus in dead harbor seals, Denmark. Emerg Infect Dis [Internet]. 2015 Apr [date cited].
DOI: 10.3201/eid2104.141484

No hay comentarios:

Publicar un comentario