National Guideline Clearinghouse | International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma.

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National Guideline Clearinghouse | International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma.



European Respiratory Society

Guideline Title

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma.

Bibliographic Source(s)

Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet LP, Brightling C, Chanez P, Dahlen SE, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014 Feb 1;43(2):343-73. [223 references] PubMed

Guideline Status

This is the current release of the guideline.

This guideline meets NGC's 2013 (revised) inclusion criteria.

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International ERS/ATS guidelines on definition, evaluation and trea... - PubMed - NCBI

Eur Respir J. 2014 Feb;43(2):343-73. doi: 10.1183/09031936.00202013. Epub 2013 Dec 12.

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma.

Chung KF1, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet LP, Brightling C, Chanez P, Dahlen SE,Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG.

Author information

Erratum in

• Eur Respir J. 2014 Apr;43(4):1216. Dosage error in article text.

Abstract

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A Task Force, supported by the European Respiratory Society and American Thoracic Society, reviewed the definition and provided recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults. A literature review was performed, followed by discussion by an expert committee according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for development of specific clinical recommendations. When the diagnosis of asthma is confirmed and comorbidities addressed, severe asthma is defined as asthma that requires treatment with high dose inhaled corticosteroids plus a second controller and/or systemic corticosteroids to prevent it from becoming "uncontrolled" or that remains "uncontrolled" despite this therapy. Severe asthma is a heterogeneous condition consisting of phenotypes such as eosinophilic asthma. Specific recommendations on the use of sputum eosinophil count and exhaled nitric oxide to guide therapy, as well as treatment with anti-IgE antibody, methotrexate, macrolide antibiotics, antifungal agents and bronchial thermoplasty are provided. Coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy.

Comment in

• Severe asthma. [Ann Am Thorac Soc. 2014]
• Comment on: International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. [Eur Respir J. 2014]
• From the authors. [Eur Respir J. 2014]
• Trustworthy guidelines on severe asthma thanks to the ERS and ATS. [Eur Respir J. 2014]
• From the authors: International European Respiratory Society/American Thoracic Society guidelines on severe asthma. [Eur Respir J. 2014]
• International European Respiratory Society/American Thoracic Society guidelines on severe asthma. [Eur Respir J. 2014]
• Comment on: International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. [Eur Respir J. 2014]

PMID:

 

24337046

 

[PubMed - indexed for MEDLINE]