domingo, 28 de diciembre de 2014

Valuations of genetic test information for treatable conditions: th... - PubMed - NCBI

Valuations of genetic test information for treatable conditions: th... - PubMed - NCBI

 2014 Dec;17(8):838-45. doi: 10.1016/j.jval.2014.09.001. Epub 2014 Nov 6.

Valuations of genetic test information for treatable conditions: the case of colorectal cancer screening.



The value of the information that genetic testing services provide can be questioned for insurance-based health systems. The results of genetic tests oftentimes may not lead to well-defined clinical interventions; however, Lynch syndrome, a genetic mutation for which carriers are at an increased risk for colorectal cancer, can be identified through genetic testing, and meaningful health interventions are available via increased colonoscopic surveillance. Valuations of test information for such conditions ought to account for the full impact of interventions and contingent outcomes.


To conduct a discrete-choice experiment to elicit individuals' preferences for genetic test information.


A Web-enabled discrete-choice experiment survey was administered to a representative sample of US residents aged 50 years and older. In addition to specifying expenditures on colonoscopies, respondents were asked to make a series of nine selections between two hypothetical genetic tests or a no-test option under the premise that a relative had Lynch syndrome. The hypothetical genetic tests were defined by the probability of developing colorectal cancer, the probability of a false-negative test result, privacy of the result, and out-of-pocket cost. A model specification identifying necessary interactions was derived from assumptions of risk behavior and the decision context and was estimated using random-parameters logit.


A total of 650 respondents were contacted, and 385 completed the survey. The monetary equivalent of test information was approximately $1800. Expenditures on colonoscopies to reduce mortality risks affected valuations. Respondents with lower income or who reported being employed significantly valued genetic tests more.


Genetic testing may confer benefits through the impact of subsequent interventions on private individuals.
Copyright © 2014. Published by Elsevier Inc.


Lynch syndrome; colorectal cancer; discrete choice experiment; genetic testing

[PubMed - in process]

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