Genomics|Update| December 4 Non Communicable Diseases ► CANCER [2]

Genomics|Update| December 4 Non Communicable Diseases

Volume 33  Number 22  December 4-11, 2014

Cancer

20 years of lesson learning: how does the ret genetic screening test impact the clinical management of medullary thyroid cancer? 
Romei C, et al. Clin Endocrinol (Oxf) 2014 Dec

Age-related clonal hematopoiesis associated with adverse outcomes. 
Jaiswal S, et al. N Engl J Med. 2014 Nov 26.

BRAF mutation in papillary thyroid cancer: A cost-utility analysis of preoperative testing 
Lee WS, et al. Surgery 2014 Dec;156(6):1569-78

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. 
Genovese G, et al. N Engl J Med. 2014 Nov 26.

Cost-effectiveness of population screening for BRCA mutations in Ashkenazi Jewish women compared with family history-based testing.
Manchanda R et al. J Natl Cancer Inst. 2014 Nov 30;107(1). pii: dju380. doi: 10.1093/jnci/dju380. Print 2015 Jan.

Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: A randomized controlled trial.
Manchanda R, et al. J Natl Cancer Inst. 2014 Nov 30;107(1). pii: dju379. doi: 10.1093/jnci/dju379. Print 2015 Jan.

Current way of detecting gene mutations misses people at high risk of cancer, Medical Xpress, Dec 1

'Screen more' for cancer risk genes, by James Gallagher, BBC, Nov 30

Diagnostic accuracy of fecal immunochemical test in average- and familial-risk colorectal cancer screening 
Cubiella J, et al. United European Gastroenterol J 2014 Dec;2(6):522-9

Genetic features of Lynch syndrome in the Israeli population 
Goldberg Y, et al. Clin Genet 2014 Nov

Identifying hereditary cancer: Genetic counseling and cancer risk assessment  
Marie Lewis K Curr Probl Cancer 2014 Oct

Implementation of a companion diagnostic in the clinical laboratory: The BRAF example in melanoma 
Mancini I, et al. Clin Chim Acta 2015 Jan;439C:128-36

Integrated Omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact. 
Lei Li et al. Nat Commun. 2014 Nov 28;5:5469.

Integration of genomic data enables selective discovery of breast cancer drivers. 
Sanchez-Garcia F, et al. Cell. 2014 Nov 25. pii: S0092-8674(14)01375-0.

Role of microsatellite instability-low as a diagnostic biomarker of Lynch syndrome in colorectal cancer
Vilar E, et al. Cancer Genet 2014 Oct

Smarter screening for cancer: Possibilities and challenges of personalization. 
Sameer D. Saini, JAMA December 3, 2014

Two studies identify a detectable, pre-cancerous state in the blood - Findings pave way for new lines of cancer research focused on detection and prevention, Broad Institute, Boston, Mass. Nov 25

Variation in pre-PCR processing of FFPE samples leads to discrepancies in BRAF and EGFR mutation detection: a diagnostic RING trial 
Kapp JR, et al. J Clin Pathol 2014 Nov

Optimizing HER2 therapy in early and advanced breast cancers, by Alice Goodman, ASCO Post, Dec 1