Genomics|Features|Prostate Cancer

Genomics|Features|Prostate Cancer

Prostate Cancer

Prostate Cancer Screening: Role for Genetics? - December 4, 2014

The problem with prostate screening, by Richard J. Ablin, New York Times, Nov 25

Recent insights

Prostate cancer risk prediction based on complete prostate cancer family history 
Albright F, et al. Prostate 2014 Nov

Prevention and early detection of prostate cancer.
Cuzick J, et al. Lancet Oncol. 2014 Oct;15(11):e484-92.

Novel commercially available genomic tests for prostate cancer: a roadmap to understanding their clinical impact. 
Davis JW. BJU Int. 2014 Sep;114(3):320-2

Copy number alteration burden predicts prostate cancer relapse.
Hieronymus H, et al. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11139-44

"It's all very well reading the letters in the genome, but it's a long way to being able to write": Men's interpretations of undergoing genetic profiling to determine future risk of prostate cancer.
Bancroft EK, et al. Fam Cancer. 2014 Dec;13(4):625-35

Prostate Cancer: Genomics & Screening - September 18, 2014

CDC information: Prostate cancer screening- A prostate specific antigen (PSA) test may find a prostate health problem, but treatment can cause serious side effects. Learn about prostate cancer and talk to your doctor before you decide to get tested or treated for prostate cancer

The U.S. Preventive Services Task Force (USPSTF) recommends against prostate-specific antigen (PSA)-based screening for prostate cancer

Talking to men about PSA testing,  by Barak Gaster, New York Times, Aug 19  

CDC information: Risk factors for prostate cancer include genetics and family history

NCI information: Genetics of prostate cancer (PDQ)

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
Al Olama AA, et al. Nat Genet. 2014 Sep 14

New genetic variants indicate risk for prostate cancer: international study, Medical News Today, Sep 17

Did you know? 995 genes have been reported in relation to prostate cancer risk and outcomes, including 81 genomewide association studies. To find out more, visit the HuGE Navigator

Incorporating genomics into breast and prostate cancer screening: assessing the implications. 
Susmita Chowdhury MD, MPhil et al. Genetics in Medicine, 2013