domingo, 5 de octubre de 2014

Full genomic characterization of a novel g... [Infect Genet Evol. 2014] - PubMed - NCBI

Full genomic characterization of a novel g... [Infect Genet Evol. 2014] - PubMed - NCBI



 2014 Sep 22. pii: S1567-1348(14)00352-9. doi: 10.1016/j.meegid.2014.09.020. [Epub ahead of print]

Full genomic characterization of a novel genotype combination, G4P[14], of a human rotavirus strain from Barbados.

Abstract

Since 2004, the Pan American Health Organization (PAHO) has carried out rotavirus surveillance in Latin America and the Caribbean. Here we report the characterization of human rotavirus with the novel G-P combination of G4P[14], detected through PAHO surveillance in Barbados. Full genome sequencing of strain RVA/Human-wt/BRB/CDC1133/2012/G4P[14] revealed that its genotype is G4-P[14]-I1-R1-C1-M1-A8-N1-T1-E1-H1. The possession of a Genogroup 1 (Wa-like) backbone distinguishes this strain from other P[14] rotavirus strains. Phylogenetic analyses suggested that this strain was likely generated by genetic reassortment between human, porcine and possibly other animal rotavirus strains and identified 7 lineages within the P[14] genotype. The results of this study reinforce the potential role of interspecies transmission in generating human rotavirus diversity through reassortment. Continued surveillance is important to determine if rotavirus vaccines will protect against strains that express the P[14] rotavirus genotype.
Copyright © 2014. Published by Elsevier B.V.

KEYWORDS:

Human; P[14]; Porcine; Reassortment; Rotavirus

PMID:
 
25251674
 
[PubMed - as supplied by publisher]

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