Am J Transplant. 2014 Sep 22. doi: 10.1111/ajt.12898. [Epub ahead of print]
Transmission of Methicillin-Resistant Staphylococcus aureus Infection Through Solid Organ Transplantation: Confirmation Via Whole Genome Sequencing.
Wendt JM1, Kaul D, Limbago BM, Ramesh M, Cohle S, Denison AM, Driebe EM, Rasheed JK, Zaki SR, Blau DM, Paddock CD, McDougal LK, Engelthaler DM,Keim PS, Roe CC, Akselrod H, Kuehnert MJ, Basavaraju SV.
We describe two cases of donor-derived methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that developed after transplantation of organs from a common donor who died from acute MRSA endocarditis. Both recipients developed recurrent MRSA infection despite appropriate antibiotic therapy, and required prolonged hospitalization and hospital readmission. Comparison of S. aureus whole genome sequence of DNA extracted from fixed donor tissue and recipients' isolates confirmed donor-derived transmission. Current guidelines emphasize the risk posed by donors with bacteremia from multidrug-resistant organisms. This investigation suggests that, particularly in the setting of donor endocarditis, even a standard course of prophylactic antibiotics may not be sufficient to prevent donor-derived infection.
© Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.
- [PubMed - as supplied by publisher]