Scientists Create Tiny Stomachs From Stem Cells

Feat may help researchers learn more about causes of stomach diseases

By Robert Preidt

Wednesday, October 29, 2014

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WEDNESDAY, Oct. 29, 2014 (HealthDay News) -- Scientists who used stem cells to create miniature human stomachs in the laboratory say their breakthrough could provide a new way to learn more about the development and treatment of stomach diseases.

The team used human pluripotent stem cells -- which can become any type of cell in the body -- to grow the functional miniature stomachs, to study infection by H. pylori bacteria, a major cause of ulcers and stomach cancer.

The miniature stomachs offer many research opportunities, including modeling early stages of stomach cancer, developing new drugs and learning more about obesity-related diabetes, according to principal investigator Jim Wells. He's a scientist in the developmental biology and endocrinology divisions at Cincinnati Children's Hospital Medical Center.

"Until this study, no one had generated gastric [stomach] cells from human pluripotent stem cells. In addition, we discovered how to promote formation of three-dimensional gastric tissue with complex architecture and cellular composition," he said in a medical center news release.

The ability to create human stomachs in the lab is important because significant structural differences in mouse stomachs make them less than ideal for studying human stomach development and disease, Wells explained.

The study was published Oct. 29 in the journal Nature.

SOURCE: Cincinnati Children's Hospital Medical Center, news release, Oct. 29, 2014

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