J Infect Dis. 2014 Jun 27. pii: jiu367. [Epub ahead of print]
Immunoglobulin Genes Influence the Magnitude of Humoral Immunity to Cytomegalovirus Glycoprotein B.
Pandey JP1, Kistner-Griffin E2, Radwan FF1, Kaur N1, Namboodiri AM1, Black L1, Butler MA3, Carreón T3, Ruder AM3.
Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (γ marker) genotypes: Anti-HCMV gB antibody levels were the highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and the lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 µg/mL, respectively; p=0.014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases.
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