lunes, 21 de julio de 2014

Immunoglobulin Genes Influence the Magnitude of... [J Infect Dis. 2014] - PubMed - NCBI

Immunoglobulin Genes Influence the Magnitude of... [J Infect Dis. 2014] - PubMed - NCBI



 2014 Jun 27. pii: jiu367. [Epub ahead of print]

Immunoglobulin Genes Influence the Magnitude of Humoral Immunity to Cytomegalovirus Glycoprotein B.

Abstract

Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (γ marker) genotypes: Anti-HCMV gB antibody levels were the highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and the lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 µg/mL, respectively; p=0.014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases.
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

PMID:
 
24973460
 
[PubMed - as supplied by publisher]

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