J Clin Microbiol. 2014 Jul 2. pii: JCM.01535-14. [Epub ahead of print]
Advances in Laboratory Methods for Detection and Typing of Norovirus.
Human noroviruses are the leading cause of epidemic and sporadic gastroenteritis across all age groups. Although the disease is usually self-limiting, in the United States norovirus gastroenteritis causes an estimated 56,000-71,000 hospitalizations and 570-800 deaths each year. This minireview describes the latest data on laboratory methods (molecular, immunological) for norovirus detection including real-time reverse transcription-polymerase chain reaction (RT-qPCR), commercially available immunological assays, as well as the latest FDA-cleared multi enteric pathogens platforms. In addition, an overview is provided on the latest nomenclature and molecular epidemiology of human noroviruses.
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