Int J Cancer. 2014 May 2. doi: 10.1002/ijc.28941. [Epub ahead of print]
Relevance and efficacy of breast cancer screening in BRCA1 and BRCA2 mutation carriers above 60 years; a national cohort study.
Saadatmand S1, Vos JR, Hooning MJ, Oosterwijk JC, Koppert LB, de Bock GH, Ausems MG, van Asperen CJ, Aalfs CM, Gómez Garcia EB, Meijers-Heijboer H,Hoogerbrugge N, Piek M; the Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Seynaeve C, Verhoef C, Rookus M, Tilanus-Linthorst MM.
Annual MRI and mammography is recommended for BRCA12 mutation carriers to reduce breast cancer mortality. Less intensive screening is advised ≥60 years, although effectiveness is unknown. We identified BRCA1/2 mutation carriers without bilateral mastectomy before age 60 to determine for whom screening ≥60 is relevant, in the Rotterdam Family Cancer Clinic and HEBON: a nationwide prospective cohort study. Furthermore, we compared tumour stage at breast cancer diagnosis between different screening strategies in BRCA1/2 mutation carriers ≥60. Tumours>2 cm, positive lymph nodes, or distant metastases at detection were defined as 'unfavourable'. Of 548 BRCA1/2 mutation carriers ≥60 years in 2012, 395 (72%) did not have bilateral mastectomy before the age of 60. Of these 395, 224 (57%) had a history of breast or other invasive carcinoma. In 136 BRCA1/2 mutation carriers, we compared 148 breast cancers (including interval cancers) detected ≥60, of which 84 (57%) were first breast cancers. With biennial mammography 53% (30/57) of carcinomas were detected in unfavourable stage, compared to 21% (12/56) with annual mammography (adjusted odds ratio: 4·07, 95% confidence interval [1·79-9·28], p=0·001). With biennial screening 40% of breast cancers were interval cancers, compared to 20% with annual screening (p=0·016). Results remained significant for BRCA1 and BRCA2 mutation carriers, and first breast cancers separately. Over 70% of 60-year old BRCA1/2 mutation carriers remain at risk for breast cancer, of which half has prior cancers. When life expectancy is good, continuation of annual breast cancer screening of BRCA1/2 mutation carriers ≥60 is worthwhile. © 2014 Wiley Periodicals, Inc.
Copyright © 2014 UICC.
BRCA1, BRCA2, breast cancer, mammography, screening
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