National Guideline Clearinghouse | Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO).

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National Guideline Clearinghouse | Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO).

Guideline Title

Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO).

 

 

Bibliographic Source(s)

Smith BD, Arthur DW, Buchholz TA, Haffty BG, Hahn CA, Hardenbergh PH, Julian TB, Marks LB, Todor DA, Vicini FA, Whelan TJ, White J, Wo JY, Harris JR. Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). Int J Radiat Oncol Biol Phys 2009 Jul 15;74(4):987-1001. [98 references] PubMed

 

 

Guideline Status

This is the current release of the guideline.

Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):987-1001.

Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO).

Smith BD, Arthur DW, Buchholz TA, Haffty BG, Hahn CA, Hardenbergh PH, Julian TB, Marks LB, Todor DA, Vicini FA, Whelan TJ, White J, Wo JY, Harris JR.

Source

Radiation Oncology Flight, Wilford Hall Medical Center, Lackland AFB, TX, USA. benjamin.smith@lackland.af.mil

Abstract

PURPOSE:

To present guidance for patients and physicians regarding the use of accelerated partial-breast irradiation (APBI), based on current published evidence complemented by expert opinion.

METHODS AND MATERIALS:

A systematic search of the National Library of Medicine's PubMed database yielded 645 candidate original research articles potentially applicable to APBI. Of these, 4 randomized trials and 38 prospective single-arm studies were identified. A Task Force composed of all authors synthesized the published evidence and, through a series of meetings, reached consensus regarding the recommendations contained herein.

RESULTS:

The Task Force proposed three patient groups: (1) a "suitable" group, for whom APBI outside of a clinical trial is acceptable, (2) a "cautionary" group, for whom caution and concern should be applied when considering APBI outside of a clinical trial, and (3) an "unsuitable" group, for whom APBI outside of a clinical trial is not generally considered warranted. Patients who choose treatment with APBI should be informed that whole-breast irradiation (WBI) is an established treatment with a much longer track record that has documented long-term effectiveness and safety.

CONCLUSION:

Accelerated partial-breast irradiation is a new technology that may ultimately demonstrate long-term effectiveness and safety comparable to that of WBI for selected patients with early breast cancer. This consensus statement is intended to provide guidance regarding the use of APBI outside of a clinical trial and to serve as a framework to promote additional clinical investigations into the optimal role of APBI in the treatment of breast cancer.

PMID:

19545784

[PubMed - indexed for MEDLINE] 

Accelerated partial breast irra... [Int J Radiat Oncol Biol Phys. 2009] - PubMed - NCBI