domingo, 30 de septiembre de 2012

Hepatitis E Virus Seroprevalence among Adults, Germany - - Emerging Infectious Disease journal - CDC

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Hepatitis E Virus Seroprevalence among Adults, Germany - - Emerging Infectious Disease journal - CDC
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Volume 18, Number 9–October 2012


Hepatitis E Virus Seroprevalence among Adults, Germany

Mirko S. Faber1Comments to Author , Jürgen J. Wenzel1, Wolfgang Jilg, Michael Thamm, Michael Höhle, and Klaus Stark
Author affiliations: Robert Koch Institute, Berlin, Germany (M.S. Faber, M. Thamm, M. Höhle, K. Stark); and University of Regensburg, Regensburg, Germany (J.J. Wenzel, W. Jilg)
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We assessed hepatitis E virus (HEV) antibody seroprevalence in a sample of the adult population in Germany. Overall HEV IgG prevalence was 16.8% (95% CI 15.6%–17.9%) and increased with age, leveling off at >60 years of age. HEV is endemic in Germany, and the lifetime risk for exposure is high.
In industrialized countries, hepatitis E virus (HEV) has long been regarded as a rare imported infection. However, sporadic cases without travel to disease-endemic areas and caused by genotype 3 are being increasingly reported (1,2). Epidemiologic and molecular studies have implicated undercooked pork and wild boar products as a source of HEV infection (35). An unexpectedly high prevalence of HEV-specific antibodies, e.g., among blood donors, has been shown by several studies in Europe and the United States (611).
In Germany, the number of notified hepatitis E cases rose from <50 0.3="0.3" 2001="2001" 2011="2011" 238="238" 3.="3." 30="30" 78="78" a="a" adult="adult" an="an" and="and" annually="annually" assay="assay" associations="associations" autochthonous="autochthonous" by="by" cases="cases" characteristics="characteristics" conducted="conducted" determine="determine" for="for" from="from" genotype="genotype" germany="germany" hev="hev" highly="highly" in="in" incidence="incidence" increased="increased" of="of" p="p" population="population" proportion="proportion" s="s" sensitive="sensitive" seroprevalence="seroprevalence" sociodemographic="sociodemographic" study="study" the="the" to="to" using="using" we="we" with="with">

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