Kyasanur forest disease virus alkhurma subtype in ticks, najran province, saudi arabia.
Mahdi M, Erickson BR, Comer JA, Nichol ST, Rollin PE, Almazroa MA, Memish ZA.
Source
Najran Preventive Medicine Department, Najran, Saudi Arabia (M. Mahdi); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (B.R. Erickson, J.A. Comer, S.T. Nichol, P.E. Rollin); and Ministry of Health, Riyadh, Saudi Arabia (M.A. AlMazroa, Z.A. Memish).
Abstract
To the Editor: The lineage of Kyasanur Forest disease virus (KFDV) found in the Kingdom of Saudi Arabia is commonly referred to as Alkhurma hemorrhagic fever virus (AHFV). This virus was first isolated from a specimen collected in 1994 from a butcher living in Makkah Province, who was hospitalized for a hemorrhagic fever from which he died (1). The virus was assigned to the genus Flavivirus on the basis of reactivity with genus-specific monoclonal antibodies and sequencing of a fragment of the nonstructural 5 (NS5) gene, which showed >89% identity with KFDV. Ten other cases were confirmed among patients who had leukopenia, thrombocytopenia, and elevated liver enzymes. Observations of patients in the original study or in a subsequent analysis (2) suggested that Alkhurma hemorrhagic fever (AHF) disease was associated with contact with blood from infected animals, bites from infected ticks, or the drinking of raw milk. However, the exact mode of transmission to humans has still not been fully elucidated. More recently, AHFV RNA was detected in a single pool of sand tampans (Ornithodoros savignyi, soft ticks), collected in western Saudi Arabia (3), which suggests a link with these ticks.
PMID:21529425[PubMed - in process]
Kyasanur forest disease virus alkhurma subtype in ... [Emerg Infect Dis. 2011] - PubMed result
.png)
No hay comentarios:
Publicar un comentario