EID Journal Home > Volume 17, Number 6–June 2011
Volume 17, Number 6–June 2011
High Vancomycin MIC and Complicated Methicillin-Susceptible Staphylococcus aureus Bacteremia
Jose Maria Aguado, Rafael San-Juan, Antonio Lalueza, Francisca Sanz, Joaquin Rodríguez-Otero, Carmen Gómez-Gonzalez, and Fernando Chaves
Author affiliations: University Hospital 12 de Octubre, Madrid, Spain
Suggested citation for this article
We conducted a retrospective study of 99 patients with methicillin-suseptible Staphylococcus aureus catheter-related bacteremia in which vancomycin MIC was determined by Etest. High vancomycin MIC (>1.5 μg/mL) was the only independent risk factor for development of complicated bacteremia caused by methicillin-susceptible S. aureus (odds ratio 22.9, 95% confidence interval 6.7–78.1).
Several studies have established a relationship between high vancomycin MIC and a worse prognosis for patients with bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) (1–5). However, to our knowledge, the role that a high vancomycin MIC could play in the clinical course of a patient with methicillin-susceptible S. aureus (MSSA) bacteremia, has not been investigated, although a high vancomycin MIC has been also reported for strains of MSSA (6).
Vancomycin MIC and MSSA Bacteremia | CDC EID
Suggested Citation for this Article
Aguado JM, San-Juan R, Lalueza A, Sanz F, Rodríguez-Otero J, Gómez-Gonzalez C, et al. High vancomycin MIC and complicated methicillin-susceptible Staphylococcus aureus bacteremia. Emerg Infect Dis [serial on the Internet]. 2011 Jun [date cited].
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Jose Maria Aguado, Complutense University of Madrid, Head, Unit of Infectious Diseases University Hospital 12 de Octubre, Madrid 28041, Spain; email: email@example.com