EID Journal Home > Volume 17, Number 6–June 2011
Volume 17, Number 6–June 2011
Increasing Ceftriaxone Resistance in Salmonellae, Taiwan
Lin-Hui Su, Wen-Shin Teng, Chyi-Liang Chen, Hao-Yuan Lee, Hsin-Chieh Li, Tsu-Lan Wu, and Cheng-Hsun Chiu
Author affiliations: Chang Gung Memorial Hospital, Taoyuan, Taiwan (L.-H. Su, H.-C. Li, T.-L. Wu); Chang Gung University College of Medicine, Taoyuan (L.-H. Su, W.-S. Teng, H.-Y. Lee, T.-L. Wu, C.-H. Chiu); and Chang Gung Children's Hospital, Taoyuan (W.-S. Teng, C.-L. Chen, H.-Y. Lee, C.-H. Chiu)
Suggested citation for this article
In Taiwan, despite a substantial decline of Salmonella enterica serotype Choleraesuis infections, strains resistant to ciprofloxacin and ceftriaxone persist. A self-transferable blaCMY-2-harboring IncI1 plasmid was identified in S. enterica serotypes Choleraesuis, Typhimurium, Agona, and Enteritidis and contributed to the overall increase of ceftriaxone resistance in salmonellae.
Salmonella enterica serotype Choleraesuis usually causes invasive infection (1). When resistant Salmonella infection is encountered, fluoroquinolones or extended-spectrum cephalosporins are frequently used (2). Fluoroquinolone resistance has been common in this invasive serotype (3). Isolation of SC-B67, a strain of S. enterica ser. Choleraesuis that was resistant to ciprofloxacin and ceftriaxone (CIPr/CROr), has exacerbated the problem (4). Ceftriaxone resistance in SC-B67 was attributed to a plasmid-mediated blaCMY-2, located on a specific ISEcp1-blaCMY-2-blc-sugE structure (4). This conserved DNA fragment, subsequently named Tn6092 (5), has been reported from different geographic areas and is widely distributed among various Salmonella serotypes and other Enterobacteriaceae (6).
Increasing Ceftriaxone Resistance in Salmonellae, Taiwan | CDC EID
Suggested Citation for this Article
Su L-H, Teng W-S, Chen C-L, Lee H-Y, Li H-C, Wu T-L, et al. Increasing ceftriaxone resistance in salmonellae, Taiwan. Emerg Infect Dis [serial on the Internet]. 2011 Jun [date cited]. http://www.cdc.gov/EID/content/17/6/1086.htm
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Cheng-Hsun Chiu, Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, 5 Fu-Hsin St, Kweishan, Taoyuan 333, Taiwan; email: email@example.com