Testing of VKORC1 and CYP2C9 alleles to guide warfarin dosing

PLoS Curr. 2010 Sep 14. pii: RRN1155.
Testing of VKORC1 and CYP2C9 alleles to guide warfarin dosing: Test Category: Pharmacogenomic (Treatment).

Grossniklaus D.

National Office of Public Health Genomics, CDC.

Abstract

Warfarin is an oral anticoagulant that is widely prescribed to prevent thromboembolic events in persons at increased risk. The optimal dose is difficult to establish because it can vary 10-fold among individuals due to clinical and demographic factors. Testing for variants of the vitamin K epoxide reductase complex 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) genes has been proposed for use in guiding the initial dose of warfarin, thus achieving optimal dosing more quickly and with lower risk of bleeding.

PMID: 20877452 [PubMed - in process]PMCID: PMC2940214

Free PMC Article
Testing of VKORC1 and CYP2C9 alleles to guide warfarin dosing