Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity — PNAS

Proc Natl Acad Sci U S A. 2010 Oct 4. [Epub ahead of print]

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.
Beekman M, Nederstigt C, Suchiman HE, Kremer D, van der Breggen R, Lakenberg N, Alemayehu WG, de Craen AJ, Westendorp RG, Boomsma DI, de Geus EJ, Houwing-Duistermaat JJ, Heijmans BT, Slagboom PE.

Molecular Epidemiology, Medical Statistics and Bioinformatics, and Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.

Abstract
A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older than 85 y of age from the general population carry the same number of disease risk alleles as young controls. Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease.

PMID: 20921414 [PubMed - as supplied by publisher]

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Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity — PNAS