Genome-wide association analysis identifies three ... [Nat Genet. 2010] - PubMed result

Nat Genet. 2010 Oct 17. [Epub ahead of print]
Genome-wide association analysis identifies three psoriasis susceptibility loci.

Stuart PE, Nair RP, Ellinghaus E, Ding J, Tejasvi T, Gudjonsson JE, Li Y, Weidinger S, Eberlein B, Gieger C, Wichmann HE, Kunz M, Ike R, Krueger GG, Bowcock AM, Mrowietz U, Lim HW, Voorhees JJ, Abecasis GR, Weichenthal M, Franke A, Rahman P, Gladman DD, Elder JT.

[1] Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA. [2] These authors contributed equally to this work.
Abstract

We carried out a meta-analysis of two recent psoriasis genome-wide association studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were followed up in a three-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified three new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4 × 10(-11)), one at FBXL19 (rs10782001, combined P = 9 × 10(-10)) and one near PSMA6-NFKBIA (rs12586317, combined P = 2 × 10(-8)). All three loci were also associated with psoriatic arthritis (rs4795067, combined P = 1 × 10(-5); rs10782001, combined P = 4 × 10(-8); and rs12586317, combined P = 6 × 10(-5)) and purely cutaneous psoriasis (rs4795067, combined P = 1 × 10(-8); rs10782001, combined P = 2 × 10(-6); and rs12586317, combined P = 1 × 10(-6)). We also replicated a recently identified association signal near RNF114 (rs495337, combined P = 2 × 10(-7)).

PMID: 20953189 [PubMed - as supplied by publisher]
Genome-wide association analysis identifies three ... [Nat Genet. 2010] - PubMed result