Genome-wide association studies identify new targe... [Sci Transl Med. 2010] - PubMed result

Sci Transl Med. 2010 Sep 8;2(48):48ps46.

Genome-wide association studies identify new targets in cardiovascular disease.
Calkin AC, Tontonoz P.

Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA.

Abstract
The prevalence of cardiovascular disease (CVD) continues to increase worldwide, highlighting the need for new therapeutic strategies. A recent meta-analysis of genome-wide association studies (GWASs) of over 100,000 individuals published in Nature identified 59 new loci associated with lipid traits; of these, a locus on chromosome 1p13 was most strongly associated with low-density lipoprotein cholesterol (LDL-C) levels. An accompanying study in Nature identified SORT1 as the causal gene at the 1p13 locus and showed that increased expression of sortilin-1 protein in liver was associated with lower LDL-C levels and a reduced risk of myocardial infarction. Together, these studies provide strong validation of the utility of GWASs in identifying biological pathways relevant to CVD pathogenesis and perhaps treatment.

PMID: 20826839 [PubMed - in process]
Genome-wide association studies identify new targe... [Sci Transl Med. 2010] - PubMed result