Variation in CDKN2A at 9p21.3 influences childhood... [Nat Genet. 2010] - PubMed result

Nat Genet. 2010 May 9. [Epub ahead of print]

Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Neira AG, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves M, Houlston RS.

[1] Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK. [2] These authors contributed equally to this work.

Abstract
Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage.

PMID: 20453839 [PubMed - as supplied by publisher]

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Variation in CDKN2A at 9p21.3 influences childhood... [Nat Genet. 2010] - PubMed result