Mechanisms of Chromosomal Instability
Sarah L. Thompson, Samuel F. Bakhoum and Duane A. Compton,
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA and Norris Cotton Cancer Center, Lebanon, NH 03766, USA
Corresponding author
Summary
Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by increasing genetic diversity among tumor cells. Here, we review the mechanisms underlying CIN, which include defects in chromosome cohesion, mitotic checkpoint function, centrosome copy number, kinetochore–microtubule attachment dynamics, and cell-cycle regulation. Understanding these mechanisms provides insight into the cellular consequences of CIN and reveals the possibility of exploiting CIN in cancer therapy.
open here please:
http://www.cell.com/current-biology/fulltext/S0960-9822(10)00076-X
blog: regreso luego de 48 horas de cambio de hábitos. Gracias a los visitantes por saber esperar y disimular el hueco de la información que se recuperará en las próximas horas. La salud amerita ser atendida y reclama algunas acciones. Muchas gracias y un cordial saludo a todos. Cerasale. Marzo 28, 2010.-
No hay comentarios:
Publicar un comentario