Uncovering how obesity leads to Alzheimer’s disease It’s long been recognized that obesity in midlife significantly raises the risk of Alzheimer’s disease. A new study shows the biological mechanisms that contribute to pathogenesis. Written byAllison Whitten, PhD

Uncovering how obesity leads to Alzheimer’s disease It’s long been recognized that obesity in midlife significantly raises the risk of Alzheimer’s disease. A new study shows the biological mechanisms that contribute to pathogenesis. Written byAllison Whitten, PhD https://www.drugdiscoverynews.com/uncovering-how-obesity-leads-to-alzheimer-s-disease-17179?utm_campaign=DDN_Newsletter_Dose&utm_medium=email&_hsenc=p2ANqtz--Ma_mRbio0_Tb9p1to7Y9ISzL1XmEa_xhjnMoEFiDVDEmPIT-1hTcTtKZhzWoSY1eBl32o4-zZ5EsBrrMU2kBmqtBvTQ&_hsmi=434969664&utm_content=434969664&utm_source=hs_email The biggest risk factor in the development of Alzheimer’s disease (AD) is one that can’t be controlled: the act of aging itself. But there are other risk factors that lay the groundwork for the disease earlier in life that can be changed — like obesity during midlife. The presence of obesity in middle age can mean up to a 74 percent increased risk of developing dementia, clearly signaling a key relationship between excess adipose tissue and neurodegeneration in the brain. Yet, the biological mechanisms linking the two have remained a mystery.