Low Accuracy of Self-Reported Family History of Melanoma in High-Risk Patients

Nicholas D Flint 1, Michael D Bishop 1, Tristan C Smart 2, Jennifer L Strunck 1, Kenneth M Boucher 2 3, Douglas Grossman 2 4, Aaron M Secrest 5 6 7

Affiliations

PMID: 32436000
DOI: 10.1007/s10689-020-00187-0

Abstract

Family history of melanoma is a major melanoma risk factor. However, self-reported family histories for some cancers, including melanoma, are commonly inaccurate. We used a unique database, the Utah Population Database (UPDB), as well as the Utah Cancer Registry to determine the accuracy of self-reported family history of melanoma in a large cohort of high-risk patients. Patient charts were reviewed and compared to records in the UPDB and the UCR to confirm personal and family history of melanoma in 1780 patients enrolled in a total body photography monitoring program. Self-reported family history of melanoma in first-degree relatives had an overall sensitivity of 71%, specificity of 79%, PPV of 31%, and NPV of 95%, with decreased accuracy (PPV) for second-degree relatives. A personal history of melanoma was the only factor significantly associated with accuracy in self-reported family history of melanoma. Patient age, sex, estimated nevus count, and number of prior personal melanomas were not significant predictors. Dermatologists should educate patients on the differences between melanomas, keratinocyte carcinomas, and pre-cancers. Confirming self-reported family history of melanoma may improve risk assessment for patients undergoing screening.

Keywords: Diagnosis; Family; Melanoma; Risk factors; Skin neoplasms.