Seeking the immune system’s sweet spot
Many of the drugs under scrutiny for fighting COVID-19 are anti-inflammatory agents. Researchers hope that these could keep in check the runaway immune responses — called cytokine storms — that seem to cause dangerous respiratory problems in some people. But a growing number of frontline critical-care physicians are advocating a more nuanced approach. They say the goal should be to nudge people towards a ‘Goldilocks’ level of immune activity: not so hot as to cause organ failure, and not so cold that the virus can run amok.
Nature Reviews Drug Discovery | 14 min read
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