CIENCIASMEDICASNEWS: Medical News | Medical Articles: Using a Bridging Assay for Anti-Drug Antibody Detection

miércoles, 28 de agosto de 2019

Medical News | Medical Articles: Using a Bridging Assay for Anti-Drug Antibody Detection

	August 28, 2019
	Antibodies
	The latest antibodies news from News Medical

Using a Bridging Assay for Anti-Drug Antibody Detection

Therapeutic drugs that are based on biological materials, like fusion proteins, enzymes, cytokines, hormones, and antibodies, may have the potential to trigger an immune response in the host. Immunogenicity of a therapeutic can be described as the undesirable stimulation of an immune response by the host to the therapeutic.

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			Storing and Handling Antibodies for Research Antibodies are proteins produced by the immune system as part of the body's defense against pathogens. Each antibody is specific to one molecule or a small number of molecules, known as antigens. Antibodies are commonly used in research to understand disease processes. However, care must be taken when handling and storing these proteins.

			Improving the Safety of Biotherapeutics: Tracing the Protease Inhibitor AEBSF with RPLC-UV This article describes how RPLC-UV can be used to remove the common protease inhibitor, AEBSF, from antibody preparations for therapeutic applications.

	Antibody Applications Antibodies are proteins that can bind to specific molecules called antigens. They have different portions in their Y-shaped structure that can bind to antigens and effector molecules. Several types of antibodies such as primary and secondary and monoclonal and polyclonal antibodies with varying specificities have been developed in recent years.

	Current and Future Applications of Rabbit Monoclonal Antibodies In most clinical applications, the monoclonal antibodies (mAbs) used are usually of murine origin; however, the small spleen of the mouse is limited in its ability to generate antibodies.

	HIV Suppression Using Adenovirus-Mediated Gene Therapy Research on therapies against the Human Immunodeficiency Virus (HIV) has repeatedly demonstrated the potential of broadly neutralizing antibodies (bn-Abs) as successful therapeutic agents. Injection of such antibodies leads to a decrease in viral concentrations in blood. However, repeated injections are necessary to prevent the recovery of the virus.

	Antibody may help the immune system fight sepsis-related fungal infections An antibody that blocks the "programmed cell death" pathway may help the immune system fight off sepsis-related fungal infections, according to animal studies reported in SHOCK: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, Official Journal of the Shock Society.