iPSC-Derived Dopaminergic Neurons for Parkinson’s Disease - ScienceDirect

iPSC-Derived Dopaminergic Neurons for Parkinson’s Disease - ScienceDirect

Reference Module in Biomedical Sciences

Encyclopedia of Tissue Engineering and Regenerative Medicine

2019, Pages 483-492

iPSC-Derived Dopaminergic Neurons for Parkinson’s Disease

Author links open overlay panelPhilipSeiblerChristineKlein

https://doi.org/10.1016/B978-0-12-801238-3.65501-0Get rights and content

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder resulting from the death of midbrain dopaminergic neurons and currently remains incurable despite enormous research efforts. The development of induced pluripotent stem cell (iPSC) technology offers the unique possibility to study disease mechanisms in any human tissue including patient-derived dopaminergic neurons. Of particular interest are the inherited monogenic forms of PD as they closely resemble the more common “idiopathic” PD and, through the mutated protein, provide a clear research target. This review provides an overview on the findings of iPSC-based genetic PD studies and explores them for unifying theories underlying PD disease mechanisms.

Keywords

DJ-1

Dopaminergic neurons

Glucocerebrosidase

Induced pluripotent stem cells

LRRK2

Lysosomes

Mitochondria

Neurodegenerative

Parkin

Parkinson’s disease

PINK1

SNCA

Substantia nigra pars compacta