Proximity to muscle cells may promote spread of prostate cancer cells, NIH study suggests

Prostate cancer cells fuse when co-cultured with muscle cells.

From left to right: prostate cancer cells (square) near skeletal (oblong) and smooth (oval) muscle cells respond to Interleukins 4 and 13 (IL4/13) by producing annexin A5 and syncytin 1 (Syn1 & AnxA5) and fusing. Fused cells (starburst) develop increased capacity to invade tissue and spread.Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health

What

Proximity to nearby muscle cells may make prostate cancer cells more likely to invade nearby tissues and spread to other organs, according to an early study by researchers at the National Institutes of Health. The presence of muscle cells appears to make cancer cells more likely to fuse two or more cancer cells into a single cell, thereby increasing their invasiveness and ability to spread. The study was led by Berna Uygur, Ph.D., of NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and includes colleagues from the National Eye Institute and the Maine Medical Center Research Institute in Scarborough. The study appears in Molecular Cancer Research.

Researchers grew human prostate cancer cells in laboratory dishes along with human muscle cells—stand-ins for the smooth muscle surrounding the prostate gland and the striated muscle of the urethral sphincter at the base of the prostate. The muscle cells secreted interleukins 4 and 13, cellular proteins that stimulated the cancer cells to produce two additional proteins, annexin A5 and syncytin 1, which triggered the cancer cells to fuse together. Testing revealed that the fused cells developed characteristics of more malignant cells, which are more likely to invade surrounding tissues and spread to other parts of the body. The researchers note that drugs to inhibit annexin A5 and syncytin 1 could be studied for their potential to treat prostate cancer. According to the National Cancer Institute, approximately 11.2 percent of men in the United States will be diagnosed with prostate cancer at some point during their lifetime.

Who

Leonid Chernomordik, Ph.D., senior investigator in the NICHD Section on Membrane Biology, is available for interviews.

Article

Uygur, B, et al. Interactions with muscle cells boost fusion, stemness, and drug resistance of prostate cancer cells. Molecular Cancer Research. 2018.

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