Added text to state that data are limited as to how much of the reduction in mortality, seen over time from 1990 onward, is attributable to advances in imaging techniques for screening and as to how much is the result of the improved effectiveness of therapy. Also added text about one Cancer Intervention and Surveillance Modeling Network (CISNET) study of simulation models that found that about one-third of the decrease in breast cancer mortality in 2012 was attributable to screening, with the balance attributed to treatment; in this CISNET study, the mean estimated reduction in overall breast cancer mortality rate was 49%, relative to the estimated baseline rate in 2012 if there was no screening or treatment—37% of this reduction was associated with screening, and 63% of this reduction was associated with treatment (cited Plevritis et al. as reference 78).
Added text about a population-based study in the Netherlands that showed that about one-half of all screen-detected breast cancers, including ductal carcinoma in situ, would represent overdiagnosis and is consistent with other studies, which showed substantial rates of overdiagnosis associated with screening (cited Autier et al. as reference 93).
ver historia personal en: www.cerasale.com.ar [dado de baja por la Cancillería Argentina por temas políticos, propio de la censura que rige en nuestro medio]//
weblog.maimonides.edu/farmacia/archives/UM_Informe_Autoevaluacion_FyB.pdf - //
weblog.maimonides.edu/farmacia/archives/0216_Admin_FarmEcon.pdf - //
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