Genetics of Prostate Cancer (PDQ®)–Health Professional Version

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Changes to This Summary (05/10/2018)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Identifying Genes and Inherited Variants Associated With Prostate Cancer Risk

Revised text to state that linkage analysis statistically compares the genotypes between affected and unaffected individuals within the extended family and looks for associations between inherited genetic markers and the disease trait; if an association between a variation at a particular chromosomal region and the disease trait is found, it provides statistical evidence that the genetic locus harbors a disease susceptibility gene.

The Susceptibility loci identified in linkage analyses subsection was extensively revised.

Added text to state that the application of a genetic score in the placebo arm of the Prostate Cancer Prevention Trial demonstrated that genotypes across multiple risk single nucleotide polymorphisms modestly supplement family history information when stratifying patients for prostate cancer risk (cited Chen et al. as reference 122).

This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.

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